Tissue expression of OXTR - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	OXTR
Gene description	Oxytocin receptor
Protein class	FDA approved drug targets G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (breast)
GTEx:	Tissue enhanced (breast)
FANTOM5:	Tissue enriched (breast)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (breast)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (breast)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (breast)

GENE INFORMATION
Gene name	OXTR
Synonyms
Description	Oxytocin receptor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p25.3
Chromosome location (bp)	8750408 - 8769628
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180914 (version 83.38)
Entrez gene	5021
UniProt	P30559 (UniProt - Evidence at transcript level)
neXtProt	NX_P30559
Antibodypedia	OXTR antibodies

PROTEIN BROWSER

OXTR-001	OXTR-002	OXTR-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OXTR-001 ENSP00000324270 ENST00000316793	P30559 [Direct mapping] Oxytocin receptor B2R9L7 [Target identity:100%; Query identity:100%] Oxytocin receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001967 [suckling behavior] GO:0001975 [response to amphetamine] GO:0001992 [regulation of systemic arterial blood pressure by vasopressin] GO:0004930 [G-protein coupled receptor activity] GO:0004990 [oxytocin receptor activity] GO:0005000 [vasopressin receptor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005902 [microvillus] GO:0005913 [cell-cell adherens junction] GO:0006936 [muscle contraction] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007507 [heart development] GO:0007565 [female pregnancy] GO:0007595 [lactation] GO:0007613 [memory] GO:0010701 [positive regulation of norepinephrine secretion] GO:0014070 [response to organic cyclic compound] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0017046 [peptide hormone binding] GO:0021537 [telencephalon development] GO:0030431 [sleep] GO:0032230 [positive regulation of synaptic transmission, GABAergic] GO:0032355 [response to estradiol] GO:0032570 [response to progesterone] GO:0032870 [cellular response to hormone stimulus] GO:0034059 [response to anoxia] GO:0034097 [response to cytokine] GO:0035176 [social behavior] GO:0042220 [response to cocaine] GO:0042277 [peptide binding] GO:0042493 [response to drug] GO:0042711 [maternal behavior] GO:0042713 [sperm ejaculation] GO:0042755 [eating behavior] GO:0043434 [response to peptide hormone] GO:0044058 [regulation of digestive system process] GO:0044849 [estrous cycle] GO:0045777 [positive regulation of blood pressure] GO:0045907 [positive regulation of vasoconstriction] GO:0048545 [response to steroid hormone] GO:0048565 [digestive tract development] GO:0051965 [positive regulation of synapse assembly] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0060137 [maternal process involved in parturition] GO:0060406 [positive regulation of penile erection] GO:0060455 [negative regulation of gastric acid secretion] GO:0070371 [ERK1 and ERK2 cascade] GO:0070474 [positive regulation of uterine smooth muscle contraction] GO:1901652 [response to peptide] Show all	389 aa 42.8 kDa	No	7
OXTR-002 ENSP00000414828 ENST00000431493	C9JQC4 [Direct mapping] Oxytocin receptor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001992 [regulation of systemic arterial blood pressure by vasopressin] GO:0004990 [oxytocin receptor activity] GO:0005000 [vasopressin receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0032870 [cellular response to hormone stimulus] GO:0035176 [social behavior] GO:0042277 [peptide binding] GO:0042711 [maternal behavior] GO:0045907 [positive regulation of vasoconstriction] GO:1901652 [response to peptide] Show all	43 aa 4.3 kDa	No	0
OXTR-004 ENSP00000389587 ENST00000449615	C9JN09 [Direct mapping] Oxytocin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001992 [regulation of systemic arterial blood pressure by vasopressin] GO:0004990 [oxytocin receptor activity] GO:0005000 [vasopressin receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0032870 [cellular response to hormone stimulus] GO:0035176 [social behavior] GO:0042277 [peptide binding] GO:0042711 [maternal behavior] GO:0045907 [positive regulation of vasoconstriction] GO:1901652 [response to peptide] Show all	92 aa 9.7 kDa	No	1