Expression of AATK in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	AATK
Gene description	Apoptosis-associated tyrosine kinase
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (CACO-2, SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, duodenum)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression of varying levels in most tissues, including neuronal cells of cerebral cortex.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA009073
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA009073

GENE INFORMATION
Gene name	AATK (HGNC Symbol)
Synonyms	AATYK, AATYK1, KIAA0641, LMR1, LMTK1, PPP1R77
Description	Apoptosis-associated tyrosine kinase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	81117295 - 81166077
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181409 (version 83.38)
Entrez gene	9625
UniProt	Q6ZMQ8 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZMQ8
Antibodypedia	AATK antibodies

PROTEIN BROWSER

AATK-001	AATK-002	AATK-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AATK-001 ENSP00000324196 ENST00000326724	Q6ZMQ8 [Direct mapping] Serine/threonine-protein kinase LMTK1 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005783 [endoplasmic reticulum] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007420 [brain development] GO:0016021 [integral component of membrane] GO:0030517 [negative regulation of axon extension] GO:0032482 [Rab protein signal transduction] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0044295 [axonal growth cone] GO:0046777 [protein autophosphorylation] GO:0048471 [perinuclear region of cytoplasm] GO:0051402 [neuron apoptotic process] GO:0055037 [recycling endosome] Show all	1374 aa 144.6 kDa	No	1
AATK-002 ENSP00000398796 ENST00000417379	H7C175 [Direct mapping] Serine/threonine-protein kinase LMTK1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	1271 aa 133.8 kDa	No	0
AATK-006 ENSP00000460202 ENST00000575363	I3L360 [Direct mapping] Serine/threonine-protein kinase LMTK1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] Show all	116 aa 12.5 kDa	No	0