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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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AATK
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    TISSUE

  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

AATK

Gene description

Apoptosis-associated tyrosine kinase

Protein class

Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (cerebral cortex, duodenum)
GTEx:Mixed
FANTOM5:Tissue enhanced (brain, cerebellum, hippocampus)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression of varying levels in most tissues, including neuronal cells of cerebral cortex.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 1 antibody.
HPA009073
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, cerebellum, hippocampus)

GENE INFORMATION

Gene name

AATK (HGNC Symbol)

Synonyms

AATYK, AATYK1, KIAA0641, LMR1, LMTK1, PPP1R77

Description

Apoptosis-associated tyrosine kinase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Chromosome

17

Cytoband

q25.3

Chromosome location (bp)

81117295 - 81166077

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000181409 (version 83.38)

Entrez gene

9625

UniProt

Q6ZMQ8 (UniProt - Evidence at protein level)

neXtProt

NX_Q6ZMQ8

Antibodypedia

AATK antibodies

PROTEIN BROWSER

AATK-001
AATK-002
AATK-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AATK-001
ENSP00000324196
ENST00000326724
Q6ZMQ8 [Direct mapping]
Serine/threonine-protein kinase LMTK1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005783 [endoplasmic reticulum]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007420 [brain development]
GO:0016021 [integral component of membrane]
GO:0030517 [negative regulation of axon extension]
GO:0032482 [Rab protein signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0044295 [axonal growth cone]
GO:0046777 [protein autophosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051402 [neuron apoptotic process]
GO:0055037 [recycling endosome]
Show all
1374 aa
144.6 kDa
No 1
AATK-002
ENSP00000398796
ENST00000417379
H7C175 [Direct mapping]
Serine/threonine-protein kinase LMTK1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
1271 aa
133.8 kDa
No 0
AATK-006
ENSP00000460202
ENST00000575363
I3L360 [Direct mapping]
Serine/threonine-protein kinase LMTK1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
116 aa
12.5 kDa
No 0

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