Tissue expression of AATK - Summary - The Human Protein Atlas

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AATK

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	AATK
Gene description	Apoptosis-associated tyrosine kinase
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex, duodenum)
GTEx:	Mixed
FANTOM5:	Tissue enhanced (brain, cerebellum, hippocampus)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression of varying levels in most tissues, including neuronal cells of cerebral cortex.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA009073
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, duodenum)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (brain, cerebellum, hippocampus)

GENE INFORMATION
Gene name	AATK (HGNC Symbol)
Synonyms	AATYK, AATYK1, KIAA0641, LMR1, LMTK1, PPP1R77
Description	Apoptosis-associated tyrosine kinase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	81117295 - 81166077
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181409 (version 83.38)
Entrez gene	9625
UniProt	Q6ZMQ8 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZMQ8
Antibodypedia	AATK antibodies

PROTEIN BROWSER

AATK-001	AATK-002	AATK-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AATK-001 ENSP00000324196 ENST00000326724	Q6ZMQ8 [Direct mapping] Serine/threonine-protein kinase LMTK1 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005783 [endoplasmic reticulum] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007420 [brain development] GO:0016021 [integral component of membrane] GO:0030517 [negative regulation of axon extension] GO:0032482 [Rab protein signal transduction] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0044295 [axonal growth cone] GO:0046777 [protein autophosphorylation] GO:0048471 [perinuclear region of cytoplasm] GO:0051402 [neuron apoptotic process] GO:0055037 [recycling endosome] Show all	1374 aa 144.6 kDa	No	1
AATK-002 ENSP00000398796 ENST00000417379	H7C175 [Direct mapping] Serine/threonine-protein kinase LMTK1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	1271 aa 133.8 kDa	No	0
AATK-006 ENSP00000460202 ENST00000575363	I3L360 [Direct mapping] Serine/threonine-protein kinase LMTK1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] Show all	116 aa 12.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.