Expression of CLDN7 in cancer - Summary - The Human Protein Atlas

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CLDN7

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLDN7
Gene description	Claudin 7
Protein class	Cancer-related genes Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CAPAN-2, HaCaT, MCF7, SK-BR-3)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct membranous expression in most glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA014703 , CAB013063
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), thyroid cancer (favourable) and stomach cancer (favourable).
Renal cancer p<0.001 Thyroid cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014703	CAB013063

GENE INFORMATION
Gene name	CLDN7 (HGNC Symbol)
Synonyms	CEPTRL2, CPETRL2, Hs.84359
Description	Claudin 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7259903 - 7263983
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181885 (version 83.38)
Entrez gene	1366
UniProt	O95471 (UniProt - Evidence at protein level)
neXtProt	NX_O95471
Antibodypedia	CLDN7 antibodies

PROTEIN BROWSER

CLDN7-001	CLDN7-003	CLDN7-004	CLDN7-006	CLDN7-007	CLDN7-008	CLDN7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLDN7-001 ENSP00000353475 ENST00000360325	O95471 [Direct mapping] Claudin-7 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0007162 [negative regulation of cell adhesion] GO:0008284 [positive regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016327 [apicolateral plasma membrane] GO:0016328 [lateral plasma membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0032463 [negative regulation of protein homooligomerization] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0050839 [cell adhesion molecule binding] GO:2000147 [positive regulation of cell motility] Show all	211 aa 22.4 kDa	Yes	3
CLDN7-003 ENSP00000396638 ENST00000397317	O95471 [Direct mapping] Claudin-7 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] GO:0016328 [lateral plasma membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0042802 [identical protein binding] Show all	211 aa 22.4 kDa	Yes	3
CLDN7-004 ENSP00000467220 ENST00000571932	K7EP40 [Direct mapping] Claudin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] Show all	129 aa 13.6 kDa	Yes	1
CLDN7-006 ENSP00000460796 ENST00000575313	I3L3X1 [Direct mapping] Claudin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] Show all	194 aa 20.7 kDa	No	3
CLDN7-007 ENSP00000460550 ENST00000574070	I3L3L6 [Direct mapping] Claudin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] Show all	100 aa 10.5 kDa	Yes	2
CLDN7-008 ENSP00000465963 ENST00000571881	K7EL87 [Direct mapping] Claudin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] Show all	140 aa 15.1 kDa	Yes	0
CLDN7-201 ENSP00000445131 ENST00000538261	F5H496 [Direct mapping] Claudin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] Show all	145 aa 15.2 kDa	Yes	2

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