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MRPS11

GENERAL INFORMATION

Gene name

 MRPS11

Gene description

 Mitochondrial ribosomal protein S11

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA043752 , HPA050345
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable) and ovarian cancer (favourable).
Cervical cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043752
HPA050345

GENE INFORMATION

Gene name

 MRPS11 (HGNC Symbol)

Synonyms

 FLJ22512, FLJ23406, HCC-2

Description

 Mitochondrial ribosomal protein S11 (HGNC Symbol)

Entrez gene summary

 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Sequence analysis identified two transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q25.3

Chromosome location (bp)

 88467453 - 88480773

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000181991 (version 83.38)

Entrez gene

 64963

UniProt

 P82912 (UniProt - Evidence at protein level)

neXtProt

 NX_P82912

Antibodypedia

 MRPS11 antibodies

PROTEIN BROWSER
MRPS11-001
MRPS11-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPS11-001
ENSP00000317376
ENST00000325844
P82912 [Direct mapping]
28S ribosomal protein S11, mitochondrial
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Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000028 [ribosomal small subunit assembly]
GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0003735 [structural constituent of ribosome]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005763 [mitochondrial small ribosomal subunit]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0044822 [poly(A) RNA binding]
GO:0048027 [mRNA 5'-UTR binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
GO:0070181 [small ribosomal subunit rRNA binding]
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 194 aa
20.6 kDa 		No 0
MRPS11-002
ENSP00000318054
ENST00000353598
P82912 [Direct mapping]
28S ribosomal protein S11, mitochondrial
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Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000028 [ribosomal small subunit assembly]
GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0003735 [structural constituent of ribosome]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005763 [mitochondrial small ribosomal subunit]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0044822 [poly(A) RNA binding]
GO:0048027 [mRNA 5'-UTR binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
GO:0070181 [small ribosomal subunit rRNA binding]
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 161 aa
16.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.