Expression of CREB3L2 in cancer - Summary - The Human Protein Atlas

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CREB3L2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CREB3L2
Gene description	CAMP responsive element binding protein 3-like 2
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Predicted membrane proteins Transcription factors
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression with additional membrane expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA015068
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015068

GENE INFORMATION
Gene name	CREB3L2 (HGNC Symbol)
Synonyms	BBF2H7, TCAG_1951439
Description	CAMP responsive element binding protein 3-like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Chromosome	7
Cytoband	q33
Chromosome location (bp)	137874979 - 138002067
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182158 (version 83.38)
Entrez gene	64764
UniProt	Q70SY1 (UniProt - Evidence at protein level)
neXtProt	NX_Q70SY1
Antibodypedia	CREB3L2 antibodies

PROTEIN BROWSER

CREB3L2-001	CREB3L2-002	CREB3L2-003	CREB3L2-005	CREB3L2-006	CREB3L2-201	CREB3L2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CREB3L2-001 ENSP00000329140 ENST00000330387	Q70SY1 [Direct mapping] Cyclic AMP-responsive element-binding protein 3-like protein 2 Processed cyclic AMP-responsive element-binding protein 3-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0002062 [chondrocyte differentiation] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0034976 [response to endoplasmic reticulum stress] GO:0035497 [cAMP response element binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051216 [cartilage development] Show all	520 aa 57.4 kDa	No	1
CREB3L2-002 ENSP00000403550 ENST00000456390	Q70SY1 [Direct mapping] Cyclic AMP-responsive element-binding protein 3-like protein 2 Processed cyclic AMP-responsive element-binding protein 3-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002062 [chondrocyte differentiation] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0034976 [response to endoplasmic reticulum stress] GO:0035497 [cAMP response element binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0051216 [cartilage development] Show all	460 aa 50.8 kDa	No	1
CREB3L2-003 ENSP00000410314 ENST00000452463	Q70SY1 [Direct mapping] Cyclic AMP-responsive element-binding protein 3-like protein 2 Processed cyclic AMP-responsive element-binding protein 3-like protein 2 Show all	Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002062 [chondrocyte differentiation] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0034976 [response to endoplasmic reticulum stress] GO:0035497 [cAMP response element binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0051216 [cartilage development] Show all	248 aa 27.7 kDa	No	0
CREB3L2-005 ENSP00000388917 ENST00000458726	C9JPH0 [Direct mapping] Cyclic AMP-responsive element-binding protein 3-like protein 2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0035497 [cAMP response element binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	185 aa 20.6 kDa	No	0
CREB3L2-006 ENSP00000402889 ENST00000420629	H7C1W8 [Direct mapping] Cyclic AMP-responsive element-binding protein 3-like protein 2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0035497 [cAMP response element binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	240 aa 26.9 kDa	No	0
CREB3L2-201 ENSP00000478432 ENST00000616381	A0A087WU77 [Direct mapping] Cyclic AMP-responsive element-binding protein 3-like protein 2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		150 aa 16.7 kDa	No	0
CREB3L2-202 ENSP00000478809 ENST00000620715	A0A087WUP1 [Direct mapping] Cyclic AMP-responsive element-binding protein 3-like protein 2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0035497 [cAMP response element binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	175 aa 19.3 kDa	No	0

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