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Reliability

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Cancer

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Detectable

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Detectable

Cancer

Detectable

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CREB3L2
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CREB3L2

Gene description

CAMP responsive element binding protein 3-like 2

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins
Predicted membrane proteins
Transcription factors

Predicted localization

Intracellular,Membrane

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Mainly cytoplasmic expression with additional membrane expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA015068
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

CREB3L2 (HGNC Symbol)

Synonyms

BBF2H7, TCAG_1951439

Description

CAMP responsive element binding protein 3-like 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

7

Cytoband

q33

Chromosome location (bp)

137874979 - 138002067

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000182158 (version 83.38)

Entrez gene

64764

UniProt

Q70SY1 (UniProt - Evidence at protein level)

neXtProt

NX_Q70SY1

Antibodypedia

CREB3L2 antibodies

PROTEIN BROWSER

CREB3L2-001
CREB3L2-002
CREB3L2-003
CREB3L2-005
CREB3L2-006
CREB3L2-201
CREB3L2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CREB3L2-001
ENSP00000329140
ENST00000330387
Q70SY1 [Direct mapping]
Cyclic AMP-responsive element-binding protein 3-like protein 2 Processed cyclic AMP-responsive element-binding protein 3-like protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002062 [chondrocyte differentiation]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0016021 [integral component of membrane]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035497 [cAMP response element binding]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051216 [cartilage development]
Show all
520 aa
57.4 kDa
No 1
CREB3L2-002
ENSP00000403550
ENST00000456390
Q70SY1 [Direct mapping]
Cyclic AMP-responsive element-binding protein 3-like protein 2 Processed cyclic AMP-responsive element-binding protein 3-like protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002062 [chondrocyte differentiation]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016021 [integral component of membrane]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035497 [cAMP response element binding]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051216 [cartilage development]
Show all
460 aa
50.8 kDa
No 1
CREB3L2-003
ENSP00000410314
ENST00000452463
Q70SY1 [Direct mapping]
Cyclic AMP-responsive element-binding protein 3-like protein 2 Processed cyclic AMP-responsive element-binding protein 3-like protein 2
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002062 [chondrocyte differentiation]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0016021 [integral component of membrane]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035497 [cAMP response element binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051216 [cartilage development]
Show all
248 aa
27.7 kDa
No 0
CREB3L2-005
ENSP00000388917
ENST00000458726
C9JPH0 [Direct mapping]
Cyclic AMP-responsive element-binding protein 3-like protein 2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0035497 [cAMP response element binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
185 aa
20.6 kDa
No 0
CREB3L2-006
ENSP00000402889
ENST00000420629
H7C1W8 [Direct mapping]
Cyclic AMP-responsive element-binding protein 3-like protein 2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0035497 [cAMP response element binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
240 aa
26.9 kDa
No 0
CREB3L2-201
ENSP00000478432
ENST00000616381
A0A087WU77 [Direct mapping]
Cyclic AMP-responsive element-binding protein 3-like protein 2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
150 aa
16.7 kDa
No 0
CREB3L2-202
ENSP00000478809
ENST00000620715
A0A087WUP1 [Direct mapping]
Cyclic AMP-responsive element-binding protein 3-like protein 2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0035497 [cAMP response element binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
175 aa
19.3 kDa
No 0

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