Expression of UBE2E2 in cancer - Summary - The Human Protein Atlas

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UBE2E2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	UBE2E2
Gene description	Ubiquitin-conjugating enzyme E2E 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression at variable levels in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.
Reliability score	Approved based on 4 antibodies. HPA003303 , HPA028872 , HPA030445 , CAB073417
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003303	HPA028872	HPA030445	CAB073417

GENE INFORMATION
Gene name	UBE2E2 (HGNC Symbol)
Synonyms	FLJ25157, UbcH8
Description	Ubiquitin-conjugating enzyme E2E 2 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p24.3
Chromosome location (bp)	23203020 - 23591793
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182247 (version 83.38)
Entrez gene	7325
UniProt	Q96LR5 (UniProt - Evidence at protein level)
neXtProt	NX_Q96LR5
Antibodypedia	UBE2E2 antibodies

PROTEIN BROWSER

UBE2E2-001	UBE2E2-003	UBE2E2-004	UBE2E2-201	UBE2E2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBE2E2-001 ENSP00000379931 ENST00000396703	Q96LR5 [Direct mapping] Ubiquitin-conjugating enzyme E2 E2 A0A024R2Q2 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast), isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006974 [cellular response to DNA damage stimulus] GO:0032020 [ISG15-protein conjugation] GO:0042296 [ISG15 transferase activity] GO:0061631 [ubiquitin conjugating enzyme activity] GO:0070534 [protein K63-linked ubiquitination] GO:0070936 [protein K48-linked ubiquitination] GO:0070979 [protein K11-linked ubiquitination] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] Show all	201 aa 22.3 kDa	No	0
UBE2E2-003 ENSP00000401053 ENST00000425792	Q96LR5 [Direct mapping] Ubiquitin-conjugating enzyme E2 E2 A0A024R2Q2 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast), isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006974 [cellular response to DNA damage stimulus] GO:0032020 [ISG15-protein conjugation] GO:0042296 [ISG15 transferase activity] GO:0061631 [ubiquitin conjugating enzyme activity] GO:0070534 [protein K63-linked ubiquitination] GO:0070936 [protein K48-linked ubiquitination] GO:0070979 [protein K11-linked ubiquitination] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] Show all	201 aa 22.3 kDa	No	0
UBE2E2-004 ENSP00000392800 ENST00000452894	C9J180 [Direct mapping] Ubiquitin-conjugating enzyme E2 E2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		164 aa 18.1 kDa	No	0
UBE2E2-201 ENSP00000484777 ENST00000613545	A0A087X283 [Direct mapping] Ubiquitin-conjugating enzyme E2 E2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016874 [ligase activity] Show all	94 aa 10.4 kDa	No	0
UBE2E2-202 ENSP00000486775 ENST00000628311	F8WF15 [Direct mapping] Ubiquitin-conjugating enzyme E2 E2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 9.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.