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SYNM

GENERAL INFORMATION

Gene name

 SYNM

Gene description

 Synemin, intermediate filament protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (seminal vesicle)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (smooth muscle, urinary bladder)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in smooth muscle cells, skeletal and cardiac myocytes, myoepithelial cells and peripheral nerves.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Staining in smooth muscle in several tissues is not annotated, view images.

Reliability score

 Supported based on 3 antibodies.
HPA040066 , HPA044200 , CAB017192
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (seminal vesicle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (smooth muscle, urinary bladder)

GENE INFORMATION

Gene name

 SYNM (HGNC Symbol)

Synonyms

 DMN, KIAA0353, SYN

Description

 Synemin, intermediate filament protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle. Two alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q26.3

Chromosome location (bp)

 99098217 - 99135593

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182253 (version 83.38)

Entrez gene

 23336

UniProt

 O15061 (UniProt - Evidence at protein level)

neXtProt

 NX_O15061

Antibodypedia

 SYNM antibodies

PROTEIN BROWSER
SYNM-001
SYNM-002
SYNM-003
SYNM-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYNM-001
ENSP00000336775
ENST00000336292
O15061 [Direct mapping]
Synemin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005882 [intermediate filament]
GO:0005912 [adherens junction]
GO:0008307 [structural constituent of muscle]
GO:0016020 [membrane]
GO:0017166 [vinculin binding]
GO:0019215 [intermediate filament binding]
GO:0043034 [costamere]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0060053 [neurofilament cytoskeleton]
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 1565 aa
172.9 kDa 		No 0
SYNM-002
ENSP00000472953
ENST00000594047
A0A075B7B1 [Direct mapping]
Desmuslin, isoform CRA_a; Synemin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
Show all
 1253 aa
140.2 kDa 		No 0
SYNM-003
ENSP00000453040
ENST00000560674
H0YL34 [Direct mapping]
Synemin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
Show all
 967 aa
107.1 kDa 		No 0
SYNM-004
ENSP00000330469
ENST00000328642
C9JIE4 [Direct mapping]
Synemin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
Show all
 339 aa
39.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.