Fields »
ABOUT
HELP
BLOG
KPNA2

GENERAL INFORMATION

Gene name

 KPNA2

Gene description

 Karyopherin alpha 2 (RAG cohort 1, importin alpha 1)

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in subsets of cells in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA041270 , CAB015460
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), urothelial cancer (unfavourable), colorectal cancer (favourable) and lung cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Urothelial cancer p<0.001
Colorectal cancer p<0.001
Lung cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041270
CAB015460

GENE INFORMATION

Gene name

 KPNA2 (HGNC Symbol)

Synonyms

 IPOA1, QIP2, RCH1, SRP1alpha

Description

 Karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (HGNC Symbol)

Entrez gene summary

 The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q24.2

Chromosome location (bp)

 68035519 - 68046842

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182481 (version 83.38)

Entrez gene

 3838

UniProt

 P52292 (UniProt - Evidence at protein level)

neXtProt

 NX_P52292

Antibodypedia

 KPNA2 antibodies

PROTEIN BROWSER
KPNA2-001
KPNA2-002
KPNA2-003
KPNA2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KPNA2-001
ENSP00000332455
ENST00000330459
P52292 [Direct mapping]
Importin subunit alpha-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000018 [regulation of DNA recombination]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006259 [DNA metabolic process]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006606 [protein import into nucleus]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0008139 [nuclear localization sequence binding]
GO:0008565 [protein transporter activity]
GO:0016020 [membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0042826 [histone deacetylase binding]
GO:0044822 [poly(A) RNA binding]
Show all
 529 aa
57.9 kDa 		No 0
KPNA2-002
ENSP00000438483
ENST00000537025
P52292 [Direct mapping]
Importin subunit alpha-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000018 [regulation of DNA recombination]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006259 [DNA metabolic process]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006606 [protein import into nucleus]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0008139 [nuclear localization sequence binding]
GO:0008565 [protein transporter activity]
GO:0016020 [membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0042826 [histone deacetylase binding]
GO:0044822 [poly(A) RNA binding]
Show all
 529 aa
57.9 kDa 		No 0
KPNA2-003
ENSP00000462331
ENST00000579754
J3KS65 [Direct mapping]
Importin subunit alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006606 [protein import into nucleus]
GO:0008565 [protein transporter activity]
Show all
 143 aa
16.3 kDa 		No 0
KPNA2-004
ENSP00000463602
ENST00000584026
J3QLL0 [Direct mapping]
Importin subunit alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006606 [protein import into nucleus]
GO:0008565 [protein transporter activity]
Show all
 134 aa
15.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.