Expression of LIMK2 in cancer - Summary - The Human Protein Atlas

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LIMK2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LIMK2
Gene description	LIM domain kinase 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and nuclear expression at variable levels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 3 antibodies. HPA008183 , HPA053882 , CAB019313
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008183	HPA053882	CAB019313

GENE INFORMATION
Gene name	LIMK2
Synonyms
Description	LIM domain kinase 2 (HGNC Symbol)
Entrez gene summary	There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q12.2
Chromosome location (bp)	31212239 - 31280080
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182541 (version 83.38)
Entrez gene	3985
UniProt	P53671 (UniProt - Evidence at protein level)
neXtProt	NX_P53671
Antibodypedia	LIMK2 antibodies

PROTEIN BROWSER

LIMK2-001	LIMK2-002	LIMK2-003	LIMK2-004	LIMK2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LIMK2-001 ENSP00000332687 ENST00000331728	P53671 [Direct mapping] LIM domain kinase 2 A0A024R1H6 [Target identity:100%; Query identity:100%] LIM domain kinase 2, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0008270 [zinc ion binding] GO:0016310 [phosphorylation] Show all	638 aa 72.2 kDa	No	0
LIMK2-002 ENSP00000384602 ENST00000406516	B5MC51 [Direct mapping] LIM domain kinase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0008270 [zinc ion binding] GO:0042325 [regulation of phosphorylation] Show all	629 aa 71.2 kDa	No	0
LIMK2-003 ENSP00000339916 ENST00000340552	P53671 [Direct mapping] LIM domain kinase 2 Show all	Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005801 [cis-Golgi network] GO:0006468 [protein phosphorylation] GO:0007283 [spermatogenesis] GO:0008270 [zinc ion binding] GO:0016310 [phosphorylation] GO:0042325 [regulation of phosphorylation] GO:0046982 [protein heterodimerization activity] Show all	686 aa 77.9 kDa	No	0
LIMK2-004 ENSP00000330470 ENST00000333611	P53671 [Direct mapping] LIM domain kinase 2 A0A024R1M2 [Target identity:100%; Query identity:100%] LIM domain kinase 2, isoform CRA_d Show all	Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0008270 [zinc ion binding] GO:0016310 [phosphorylation] Show all	617 aa 69.9 kDa	No	0
LIMK2-005 ENSP00000388422 ENST00000425203	C9JK61 [Direct mapping] LIM domain kinase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	82 aa 9.4 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.