We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
CSF1R
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CSF1R

Gene description

Colony stimulating factor 1 receptor

Protein class

Cancer-related genes
CD markers
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Group enriched (BEWO, SK-BR-3)
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at variable levels in several different cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending retesting.

Reliability score

Uncertain based on 2 antibodies.
HPA012323 , CAB008970
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable) and testis cancer (unfavourable).
Renal cancer p<0.001
Testis cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA012323
CAB008970

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of cacner tissues showed moderate cytoplasmic staining. Strong immunoreactivity was observed in several cases of colorectal cancers, cancers of female genitalia, pancreatic and liver cancers.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of ovarian, thyroid, renal, gastric and pancreatic cancers showed moderate to strong cytoplasmic as well as nuclear positivity. Remaining cancer tissues were weakly stained.

GENE INFORMATION

Gene name

CSF1R (HGNC Symbol)

Synonyms

C-FMS, CD115, CSFR, FMS

Description

Colony stimulating factor 1 receptor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Chromosome

5

Cytoband

q32

Chromosome location (bp)

150053291 - 150113372

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000182578 (version 83.38)

Entrez gene

1436

UniProt

P07333 (UniProt - Evidence at protein level)

neXtProt

NX_P07333

Antibodypedia

CSF1R antibodies

PROTEIN BROWSER

CSF1R-001
CSF1R-004
CSF1R-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CSF1R-001
ENSP00000286301
ENST00000286301
P07333 [Direct mapping]
Macrophage colony-stimulating factor 1 receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005011 [macrophage colony-stimulating factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0007519 [skeletal muscle tissue development]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019903 [protein phosphatase binding]
GO:0019955 [cytokine binding]
GO:0021772 [olfactory bulb development]
GO:0021879 [forebrain neuron differentiation]
GO:0030097 [hemopoiesis]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030316 [osteoclast differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031529 [ruffle organization]
GO:0036006 [cellular response to macrophage colony-stimulating factor stimulus]
GO:0038145 [macrophage colony-stimulating factor signaling pathway]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0045124 [regulation of bone resorption]
GO:0045217 [cell-cell junction maintenance]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0046777 [protein autophosphorylation]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060603 [mammary gland duct morphogenesis]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0090197 [positive regulation of chemokine secretion]
GO:1990682 [CSF1-CSF1R complex]
GO:2000147 [positive regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
972 aa
108 kDa
Yes 1
CSF1R-004
ENSP00000421174
ENST00000511344
D6RGW1 [Direct mapping]
Macrophage colony-stimulating factor 1 receptor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
49 aa
5.8 kDa
No 0
CSF1R-201
ENSP00000445282
ENST00000543093
P07333 [Direct mapping]
Macrophage colony-stimulating factor 1 receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005011 [macrophage colony-stimulating factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019955 [cytokine binding]
GO:0030097 [hemopoiesis]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030316 [osteoclast differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031529 [ruffle organization]
GO:0036006 [cellular response to macrophage colony-stimulating factor stimulus]
GO:0038145 [macrophage colony-stimulating factor signaling pathway]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0045124 [regulation of bone resorption]
GO:0045217 [cell-cell junction maintenance]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0046777 [protein autophosphorylation]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060603 [mammary gland duct morphogenesis]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0090197 [positive regulation of chemokine secretion]
GO:1990682 [CSF1-CSF1R complex]
GO:2000147 [positive regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
306 aa
33.2 kDa
Yes 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.