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CSF1R

GENERAL INFORMATION

Gene name

 CSF1R

Gene description

 Colony stimulating factor 1 receptor

Protein class

 Cancer-related genes
CD markers
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enriched (spleen)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression at variable levels in several different cell types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending retesting.

Reliability score

 Uncertain based on 2 antibodies.
HPA012323 , CAB008970
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CSF1R (HGNC Symbol)

Synonyms

 C-FMS, CD115, CSFR, FMS

Description

 Colony stimulating factor 1 receptor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Chromosome

 5

Cytoband

 q32

Chromosome location (bp)

 150053291 - 150113372

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182578 (version 83.38)

Entrez gene

 1436

UniProt

 P07333 (UniProt - Evidence at protein level)

neXtProt

 NX_P07333

Antibodypedia

 CSF1R antibodies

PROTEIN BROWSER
CSF1R-001
CSF1R-004
CSF1R-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CSF1R-001
ENSP00000286301
ENST00000286301
P07333 [Direct mapping]
Macrophage colony-stimulating factor 1 receptor
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005011 [macrophage colony-stimulating factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0007519 [skeletal muscle tissue development]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019903 [protein phosphatase binding]
GO:0019955 [cytokine binding]
GO:0021772 [olfactory bulb development]
GO:0021879 [forebrain neuron differentiation]
GO:0030097 [hemopoiesis]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030316 [osteoclast differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031529 [ruffle organization]
GO:0036006 [cellular response to macrophage colony-stimulating factor stimulus]
GO:0038145 [macrophage colony-stimulating factor signaling pathway]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0045124 [regulation of bone resorption]
GO:0045217 [cell-cell junction maintenance]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0046777 [protein autophosphorylation]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060603 [mammary gland duct morphogenesis]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0090197 [positive regulation of chemokine secretion]
GO:1990682 [CSF1-CSF1R complex]
GO:2000147 [positive regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
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 972 aa
108 kDa 		Yes 1
CSF1R-004
ENSP00000421174
ENST00000511344
D6RGW1 [Direct mapping]
Macrophage colony-stimulating factor 1 receptor
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 49 aa
5.8 kDa 		No 0
CSF1R-201
ENSP00000445282
ENST00000543093
P07333 [Direct mapping]
Macrophage colony-stimulating factor 1 receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005011 [macrophage colony-stimulating factor receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019955 [cytokine binding]
GO:0030097 [hemopoiesis]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030316 [osteoclast differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031529 [ruffle organization]
GO:0036006 [cellular response to macrophage colony-stimulating factor stimulus]
GO:0038145 [macrophage colony-stimulating factor signaling pathway]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0045124 [regulation of bone resorption]
GO:0045217 [cell-cell junction maintenance]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0046777 [protein autophosphorylation]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060603 [mammary gland duct morphogenesis]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0090197 [positive regulation of chemokine secretion]
GO:1990682 [CSF1-CSF1R complex]
GO:2000147 [positive regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 306 aa
33.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.