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LCK

GENERAL INFORMATION

Gene name

 LCK

Gene description

 LCK proto-oncogene, Src family tyrosine kinase

Protein class

 Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (MOLT-4, U-698)
HPA (normal tissue):Tissue enhanced (appendix, lymph node, tonsil)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct cytoplasmic expression in immune cells in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA003494 , CAB003816
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), renal cancer (unfavourable), melanoma (favourable) and head and neck cancer (favourable).
Endometrial cancer p<0.001
Renal cancer p<0.001
Melanoma p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA003494
CAB003816

GENE INFORMATION

Gene name

 LCK

Synonyms

Description

 LCK proto-oncogene, Src family tyrosine kinase (HGNC Symbol)

Entrez gene summary

 This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p35.2

Chromosome location (bp)

 32251239 - 32286165

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182866 (version 83.38)

Entrez gene

 3932

UniProt

 P06239 (UniProt - Evidence at protein level)

neXtProt

 NX_P06239

Antibodypedia

 LCK antibodies

PROTEIN BROWSER
LCK-001
LCK-002
LCK-004
LCK-006
LCK-010
LCK-011
LCK-012
LCK-013
LCK-201
LCK-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LCK-001
ENSP00000337825
ENST00000336890
P06239 [Direct mapping]
Tyrosine-protein kinase Lck
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000242 [pericentriolar material]
GO:0001772 [immunological synapse]
GO:0001948 [glycoprotein binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006468 [protein phosphorylation]
GO:0006470 [protein dephosphorylation]
GO:0006882 [cellular zinc ion homeostasis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010628 [positive regulation of gene expression]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030097 [hemopoiesis]
GO:0030168 [platelet activation]
GO:0030217 [T cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042169 [SH2 domain binding]
GO:0042493 [response to drug]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042609 [CD4 receptor binding]
GO:0042610 [CD8 receptor binding]
GO:0042802 [identical protein binding]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045588 [positive regulation of gamma-delta T cell differentiation]
GO:0045589 [regulation of regulatory T cell differentiation]
GO:0046777 [protein autophosphorylation]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050852 [T cell receptor signaling pathway]
GO:0050853 [B cell receptor signaling pathway]
GO:0050856 [regulation of T cell receptor signaling pathway]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0050900 [leukocyte migration]
GO:0051117 [ATPase binding]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051249 [regulation of lymphocyte activation]
GO:0070062 [extracellular exosome]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:1990405 [protein antigen binding]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 509 aa
58 kDa 		No 0
LCK-002
ENSP00000431517
ENST00000482949
E9PKQ8 [Direct mapping]
Tyrosine-protein kinase Lck
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0050853 [B cell receptor signaling pathway]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 200 aa
22.2 kDa 		No 0
LCK-004
ENSP00000328213
ENST00000333070
P06239 [Direct mapping]
Tyrosine-protein kinase Lck
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000242 [pericentriolar material]
GO:0001772 [immunological synapse]
GO:0001948 [glycoprotein binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006470 [protein dephosphorylation]
GO:0006882 [cellular zinc ion homeostasis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030097 [hemopoiesis]
GO:0030168 [platelet activation]
GO:0030217 [T cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042169 [SH2 domain binding]
GO:0042493 [response to drug]
GO:0042609 [CD4 receptor binding]
GO:0042610 [CD8 receptor binding]
GO:0042802 [identical protein binding]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050852 [T cell receptor signaling pathway]
GO:0050853 [B cell receptor signaling pathway]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0050900 [leukocyte migration]
GO:0051117 [ATPase binding]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051249 [regulation of lymphocyte activation]
GO:0070062 [extracellular exosome]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 539 aa
61.2 kDa 		No 0
LCK-006
ENSP00000435605
ENST00000495610
E9PJ92 [Direct mapping]
Tyrosine-protein kinase Lck
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0050853 [B cell receptor signaling pathway]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 319 aa
36 kDa 		No 0
LCK-010
ENSP00000362658
ENST00000373557
E9PAP0 [Direct mapping]
Tyrosine-protein kinase Lck
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0050853 [B cell receptor signaling pathway]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 285 aa
31.6 kDa 		No 0
LCK-011
ENSP00000436554
ENST00000477031
E9PI33 [Direct mapping]
Tyrosine-protein kinase Lck
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0050853 [B cell receptor signaling pathway]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 168 aa
17.8 kDa 		No 0
LCK-012
ENSP00000434525
ENST00000461712
E9PQ10 [Direct mapping]
Tyrosine-protein kinase Lck
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0050853 [B cell receptor signaling pathway]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 149 aa
16.2 kDa 		No 0
LCK-013
ENSP00000362663
ENST00000373562
F8W6B9 [Direct mapping]
Tyrosine-protein kinase Lck
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0050853 [B cell receptor signaling pathway]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 137 aa
15.3 kDa 		No 0
LCK-201
ENSP00000362665
ENST00000373564
Q573B4 [Direct mapping]
Non-specific protein-tyrosine kinase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0050853 [B cell receptor signaling pathway]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 516 aa
58.3 kDa 		No 0
LCK-202
ENSP00000477713
ENST00000619559
P06239 [Direct mapping]
Tyrosine-protein kinase Lck
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000242 [pericentriolar material]
GO:0001772 [immunological synapse]
GO:0001948 [glycoprotein binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006470 [protein dephosphorylation]
GO:0006882 [cellular zinc ion homeostasis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030097 [hemopoiesis]
GO:0030168 [platelet activation]
GO:0030217 [T cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042169 [SH2 domain binding]
GO:0042493 [response to drug]
GO:0042609 [CD4 receptor binding]
GO:0042610 [CD8 receptor binding]
GO:0042802 [identical protein binding]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050852 [T cell receptor signaling pathway]
GO:0050853 [B cell receptor signaling pathway]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0050900 [leukocyte migration]
GO:0051117 [ATPase binding]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051249 [regulation of lymphocyte activation]
GO:0070062 [extracellular exosome]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 509 aa
58 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.