Expression of ABAT in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene nameⁱ Gene name according to HGNC.	ABAT
Gene descriptionⁱ Gene description according to HGNC.	4-aminobutyrate aminotransferase
Protein classⁱ Protein class the gene product belongs to according to selected gene lists. List of protein classes.	Disease related genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localizationⁱ Protein localization predicted from several bioinformatic algorithms. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcribed from this gene as defined by Ensembl.	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryⁱ

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (Hep G2, MCF7, RH-30, T-47d)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, kidney, liver)

Protein evidenceⁱ

Evidence at protein level

Protein expression
normal tissueⁱ

Granular cytoplasmic expression in a subset of tissues.

ANTIBODY IHC RELIABILITY
Data reliability descriptionⁱ Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.	Antibody staining mainly consistent with RNA expression data.
Reliability scoreⁱ Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data. Read more	Supported based on 2 antibodies. HPA041528 , HPA041690
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PROGNOSTIC SUMMARYⁱ Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Prognostic marker in renal cancer (favourable), liver cancer (favourable) and lung cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEWⁱ

TCGA datasetⁱ
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more

RNA cancer category: Expressed in all

PROTEIN EXPRESSIONⁱ

STAINING SUMMARYⁱ

HPA041528	HPA041690

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	ABAT (HGNC Symbol)
Synonyms	GABAT
Description	4-aminobutyrate aminotransferase (HGNC Symbol)
Entrez gene summary	4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p13.2
Chromosome location (bp)	8674565 - 8784575
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183044 (version 83.38)
Entrez gene	18
UniProt	P80404 (UniProt - Evidence at protein level)
neXtProt	NX_P80404
Antibodypedia	ABAT antibodies

PROTEIN BROWSERⁱ

ABAT-001	ABAT-003	ABAT-005	ABAT-006	ABAT-008	ABAT-009	ABAT-012	ABAT-013	ABAT-201

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABAT-001 ENSP00000268251 ENST00000268251	P80404 [Direct mapping] 4-aminobutyrate aminotransferase, mitochondrial X5D8S1 [Target identity:100%; Query identity:100%] 4-aminobutyrate aminotransferase isoform A Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003867 [4-aminobutyrate transaminase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0008483 [transaminase activity] GO:0009448 [gamma-aminobutyric acid metabolic process] GO:0009450 [gamma-aminobutyric acid catabolic process] GO:0030170 [pyridoxal phosphate binding] GO:0032144 [4-aminobutyrate transaminase complex] GO:0032145 [succinate-semialdehyde dehydrogenase binding] GO:0042135 [neurotransmitter catabolic process] GO:0042803 [protein homodimerization activity] GO:0046872 [metal ion binding] GO:0047298 [(S)-3-amino-2-methylpropionate transaminase activity] GO:0048148 [behavioral response to cocaine] GO:0051536 [iron-sulfur cluster binding] GO:0070062 [extracellular exosome] Show all	500 aa 56.4 kDa	No	0
ABAT-003 ENSP00000456330 ENST00000567812	H3BRN4 [Direct mapping] 4-aminobutyrate aminotransferase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003867 [4-aminobutyrate transaminase activity] GO:0008483 [transaminase activity] GO:0009058 [biosynthetic process] GO:0009448 [gamma-aminobutyric acid metabolic process] GO:0030170 [pyridoxal phosphate binding] Show all	515 aa 58.1 kDa	No	0
ABAT-005 ENSP00000411916 ENST00000425191	P80404 [Direct mapping] 4-aminobutyrate aminotransferase, mitochondrial X5D8S1 [Target identity:100%; Query identity:100%] 4-aminobutyrate aminotransferase isoform A Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003867 [4-aminobutyrate transaminase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0008483 [transaminase activity] GO:0009448 [gamma-aminobutyric acid metabolic process] GO:0009450 [gamma-aminobutyric acid catabolic process] GO:0030170 [pyridoxal phosphate binding] GO:0032144 [4-aminobutyrate transaminase complex] GO:0032145 [succinate-semialdehyde dehydrogenase binding] GO:0042135 [neurotransmitter catabolic process] GO:0042803 [protein homodimerization activity] GO:0046872 [metal ion binding] GO:0047298 [(S)-3-amino-2-methylpropionate transaminase activity] GO:0048148 [behavioral response to cocaine] GO:0051536 [iron-sulfur cluster binding] GO:0070062 [extracellular exosome] Show all	500 aa 56.4 kDa	No	0
ABAT-006 ENSP00000454963 ENST00000569156	H3BNQ7 [Direct mapping] 4-aminobutyrate aminotransferase, mitochondrial Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003867 [4-aminobutyrate transaminase activity] GO:0008483 [transaminase activity] GO:0009058 [biosynthetic process] GO:0009448 [gamma-aminobutyric acid metabolic process] GO:0030170 [pyridoxal phosphate binding] Show all	515 aa 57.9 kDa	No	0
ABAT-008 ENSP00000456392 ENST00000564714	H3BRT1 [Direct mapping] 4-aminobutyrate aminotransferase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008483 [transaminase activity] GO:0009058 [biosynthetic process] GO:0030170 [pyridoxal phosphate binding] Show all	95 aa 10.7 kDa	No	0
ABAT-009 ENSP00000455184 ENST00000568847	H3BP74 [Direct mapping] 4-aminobutyrate aminotransferase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		32 aa 3.5 kDa	No	0
ABAT-012 ENSP00000454415 ENST00000565016	H3BMJ9 [Direct mapping] 4-aminobutyrate aminotransferase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008483 [transaminase activity] GO:0009058 [biosynthetic process] GO:0030170 [pyridoxal phosphate binding] Show all	91 aa 10.2 kDa	No	0
ABAT-013 ENSP00000456267 ENST00000561870	H3BRJ1 [Direct mapping] 4-aminobutyrate aminotransferase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008483 [transaminase activity] GO:0009058 [biosynthetic process] GO:0030170 [pyridoxal phosphate binding] Show all	65 aa 7.3 kDa	No	0
ABAT-201 ENSP00000379845 ENST00000396600	P80404 [Direct mapping] 4-aminobutyrate aminotransferase, mitochondrial X5D8S1 [Target identity:100%; Query identity:100%] 4-aminobutyrate aminotransferase isoform A Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001666 [response to hypoxia] GO:0003867 [4-aminobutyrate transaminase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0007568 [aging] GO:0007620 [copulation] GO:0007626 [locomotory behavior] GO:0008483 [transaminase activity] GO:0009448 [gamma-aminobutyric acid metabolic process] GO:0009449 [gamma-aminobutyric acid biosynthetic process] GO:0009450 [gamma-aminobutyric acid catabolic process] GO:0010039 [response to iron ion] GO:0014053 [negative regulation of gamma-aminobutyric acid secretion] GO:0021549 [cerebellum development] GO:0030170 [pyridoxal phosphate binding] GO:0031652 [positive regulation of heat generation] GO:0032024 [positive regulation of insulin secretion] GO:0032144 [4-aminobutyrate transaminase complex] GO:0032145 [succinate-semialdehyde dehydrogenase binding] GO:0033602 [negative regulation of dopamine secretion] GO:0035094 [response to nicotine] GO:0035640 [exploration behavior] GO:0042135 [neurotransmitter catabolic process] GO:0042220 [response to cocaine] GO:0042493 [response to drug] GO:0042803 [protein homodimerization activity] GO:0043005 [neuron projection] GO:0045471 [response to ethanol] GO:0045776 [negative regulation of blood pressure] GO:0045964 [positive regulation of dopamine metabolic process] GO:0046872 [metal ion binding] GO:0047298 [(S)-3-amino-2-methylpropionate transaminase activity] GO:0048148 [behavioral response to cocaine] GO:0051536 [iron-sulfur cluster binding] GO:0070062 [extracellular exosome] GO:0070474 [positive regulation of uterine smooth muscle contraction] GO:0090331 [negative regulation of platelet aggregation] GO:0097151 [positive regulation of inhibitory postsynaptic potential] GO:1902722 [positive regulation of prolactin secretion] GO:1904450 [positive regulation of aspartate secretion] Show all	500 aa 56.4 kDa	No	0