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Gene name

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Chromosome

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In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

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Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

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Score

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Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ABAT

Gene description

4-aminobutyrate aminotransferase

Protein class

Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (Hep G2, MCF7, RH-30, T-47d)
HPA (normal tissue):Tissue enhanced (cerebral cortex, kidney, liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in a subset of tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA041528 , HPA041690
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable), liver cancer (favourable) and lung cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Lung cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA041528
HPA041690

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Hepatocellular carcinomas, papillary adenocarcinomas of thyroid, malignant gliomas, several breast cancers along with a few cases of colorectal, urothelial and pancreatic cancers exhibited moderate to strong granular cytoplasmic positivity. Moderate staining was observed in prostate cancers. Remaining malignant cells were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of malignant cells exhibited moderate to strong granular cytoplasmic positivity. Most cases of malignant melanomas, endometrial cancers, testicular cancers, squamous and basal cell carcinomas were negative.

GENE INFORMATION

Gene name

ABAT (HGNC Symbol)

Synonyms

GABAT

Description

4-aminobutyrate aminotransferase (HGNC Symbol)

Entrez gene summary

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

p13.2

Chromosome location (bp)

8674565 - 8784575

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000183044 (version 83.38)

Entrez gene

18

UniProt

P80404 (UniProt - Evidence at protein level)

neXtProt

NX_P80404

Antibodypedia

ABAT antibodies

PROTEIN BROWSER

ABAT-001
ABAT-003
ABAT-005
ABAT-006
ABAT-008
ABAT-009
ABAT-012
ABAT-013
ABAT-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABAT-001
ENSP00000268251
ENST00000268251
P80404 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
X5D8S1 [Target identity:100%; Query identity:100%]
4-aminobutyrate aminotransferase isoform A
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003867 [4-aminobutyrate transaminase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008483 [transaminase activity]
GO:0009448 [gamma-aminobutyric acid metabolic process]
GO:0009450 [gamma-aminobutyric acid catabolic process]
GO:0030170 [pyridoxal phosphate binding]
GO:0032144 [4-aminobutyrate transaminase complex]
GO:0032145 [succinate-semialdehyde dehydrogenase binding]
GO:0042135 [neurotransmitter catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0046872 [metal ion binding]
GO:0047298 [(S)-3-amino-2-methylpropionate transaminase activity]
GO:0048148 [behavioral response to cocaine]
GO:0051536 [iron-sulfur cluster binding]
GO:0070062 [extracellular exosome]
Show all
500 aa
56.4 kDa
No 0
ABAT-003
ENSP00000456330
ENST00000567812
H3BRN4 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003867 [4-aminobutyrate transaminase activity]
GO:0008483 [transaminase activity]
GO:0009058 [biosynthetic process]
GO:0009448 [gamma-aminobutyric acid metabolic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
515 aa
58.1 kDa
No 0
ABAT-005
ENSP00000411916
ENST00000425191
P80404 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
X5D8S1 [Target identity:100%; Query identity:100%]
4-aminobutyrate aminotransferase isoform A
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003867 [4-aminobutyrate transaminase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008483 [transaminase activity]
GO:0009448 [gamma-aminobutyric acid metabolic process]
GO:0009450 [gamma-aminobutyric acid catabolic process]
GO:0030170 [pyridoxal phosphate binding]
GO:0032144 [4-aminobutyrate transaminase complex]
GO:0032145 [succinate-semialdehyde dehydrogenase binding]
GO:0042135 [neurotransmitter catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0046872 [metal ion binding]
GO:0047298 [(S)-3-amino-2-methylpropionate transaminase activity]
GO:0048148 [behavioral response to cocaine]
GO:0051536 [iron-sulfur cluster binding]
GO:0070062 [extracellular exosome]
Show all
500 aa
56.4 kDa
No 0
ABAT-006
ENSP00000454963
ENST00000569156
H3BNQ7 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003867 [4-aminobutyrate transaminase activity]
GO:0008483 [transaminase activity]
GO:0009058 [biosynthetic process]
GO:0009448 [gamma-aminobutyric acid metabolic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
515 aa
57.9 kDa
No 0
ABAT-008
ENSP00000456392
ENST00000564714
H3BRT1 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008483 [transaminase activity]
GO:0009058 [biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
95 aa
10.7 kDa
No 0
ABAT-009
ENSP00000455184
ENST00000568847
H3BP74 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
32 aa
3.5 kDa
No 0
ABAT-012
ENSP00000454415
ENST00000565016
H3BMJ9 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008483 [transaminase activity]
GO:0009058 [biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
91 aa
10.2 kDa
No 0
ABAT-013
ENSP00000456267
ENST00000561870
H3BRJ1 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008483 [transaminase activity]
GO:0009058 [biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
65 aa
7.3 kDa
No 0
ABAT-201
ENSP00000379845
ENST00000396600
P80404 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
X5D8S1 [Target identity:100%; Query identity:100%]
4-aminobutyrate aminotransferase isoform A
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0003867 [4-aminobutyrate transaminase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007568 [aging]
GO:0007620 [copulation]
GO:0007626 [locomotory behavior]
GO:0008483 [transaminase activity]
GO:0009448 [gamma-aminobutyric acid metabolic process]
GO:0009449 [gamma-aminobutyric acid biosynthetic process]
GO:0009450 [gamma-aminobutyric acid catabolic process]
GO:0010039 [response to iron ion]
GO:0014053 [negative regulation of gamma-aminobutyric acid secretion]
GO:0021549 [cerebellum development]
GO:0030170 [pyridoxal phosphate binding]
GO:0031652 [positive regulation of heat generation]
GO:0032024 [positive regulation of insulin secretion]
GO:0032144 [4-aminobutyrate transaminase complex]
GO:0032145 [succinate-semialdehyde dehydrogenase binding]
GO:0033602 [negative regulation of dopamine secretion]
GO:0035094 [response to nicotine]
GO:0035640 [exploration behavior]
GO:0042135 [neurotransmitter catabolic process]
GO:0042220 [response to cocaine]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0045471 [response to ethanol]
GO:0045776 [negative regulation of blood pressure]
GO:0045964 [positive regulation of dopamine metabolic process]
GO:0046872 [metal ion binding]
GO:0047298 [(S)-3-amino-2-methylpropionate transaminase activity]
GO:0048148 [behavioral response to cocaine]
GO:0051536 [iron-sulfur cluster binding]
GO:0070062 [extracellular exosome]
GO:0070474 [positive regulation of uterine smooth muscle contraction]
GO:0090331 [negative regulation of platelet aggregation]
GO:0097151 [positive regulation of inhibitory postsynaptic potential]
GO:1902722 [positive regulation of prolactin secretion]
GO:1904450 [positive regulation of aspartate secretion]
Show all
500 aa
56.4 kDa
No 0

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