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ABAT
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ABAT

Gene description

4-aminobutyrate aminotransferase

Protein class

Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (cerebral cortex, kidney, liver)
GTEx:Mixed
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus, liver, pancreas, pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

Granular cytoplasmic expression in a subset of tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA041528 , HPA041690
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, kidney, liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus, liver, pancreas, pituitary gland)

GENE INFORMATION

Gene name

ABAT (HGNC Symbol)

Synonyms

GABAT

Description

4-aminobutyrate aminotransferase (HGNC Symbol)

Entrez gene summary

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

p13.2

Chromosome location (bp)

8674565 - 8784575

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000183044 (version 83.38)

Entrez gene

18

UniProt

P80404 (UniProt - Evidence at protein level)

neXtProt

NX_P80404

Antibodypedia

ABAT antibodies

PROTEIN BROWSER

ABAT-001
ABAT-003
ABAT-005
ABAT-006
ABAT-008
ABAT-009
ABAT-012
ABAT-013
ABAT-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABAT-001
ENSP00000268251
ENST00000268251
P80404 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
X5D8S1 [Target identity:100%; Query identity:100%]
4-aminobutyrate aminotransferase isoform A
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003867 [4-aminobutyrate transaminase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008483 [transaminase activity]
GO:0009448 [gamma-aminobutyric acid metabolic process]
GO:0009450 [gamma-aminobutyric acid catabolic process]
GO:0030170 [pyridoxal phosphate binding]
GO:0032144 [4-aminobutyrate transaminase complex]
GO:0032145 [succinate-semialdehyde dehydrogenase binding]
GO:0042135 [neurotransmitter catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0046872 [metal ion binding]
GO:0047298 [(S)-3-amino-2-methylpropionate transaminase activity]
GO:0048148 [behavioral response to cocaine]
GO:0051536 [iron-sulfur cluster binding]
GO:0070062 [extracellular exosome]
Show all
500 aa
56.4 kDa
No 0
ABAT-003
ENSP00000456330
ENST00000567812
H3BRN4 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003867 [4-aminobutyrate transaminase activity]
GO:0008483 [transaminase activity]
GO:0009058 [biosynthetic process]
GO:0009448 [gamma-aminobutyric acid metabolic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
515 aa
58.1 kDa
No 0
ABAT-005
ENSP00000411916
ENST00000425191
P80404 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
X5D8S1 [Target identity:100%; Query identity:100%]
4-aminobutyrate aminotransferase isoform A
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003867 [4-aminobutyrate transaminase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008483 [transaminase activity]
GO:0009448 [gamma-aminobutyric acid metabolic process]
GO:0009450 [gamma-aminobutyric acid catabolic process]
GO:0030170 [pyridoxal phosphate binding]
GO:0032144 [4-aminobutyrate transaminase complex]
GO:0032145 [succinate-semialdehyde dehydrogenase binding]
GO:0042135 [neurotransmitter catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0046872 [metal ion binding]
GO:0047298 [(S)-3-amino-2-methylpropionate transaminase activity]
GO:0048148 [behavioral response to cocaine]
GO:0051536 [iron-sulfur cluster binding]
GO:0070062 [extracellular exosome]
Show all
500 aa
56.4 kDa
No 0
ABAT-006
ENSP00000454963
ENST00000569156
H3BNQ7 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003867 [4-aminobutyrate transaminase activity]
GO:0008483 [transaminase activity]
GO:0009058 [biosynthetic process]
GO:0009448 [gamma-aminobutyric acid metabolic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
515 aa
57.9 kDa
No 0
ABAT-008
ENSP00000456392
ENST00000564714
H3BRT1 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008483 [transaminase activity]
GO:0009058 [biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
95 aa
10.7 kDa
No 0
ABAT-009
ENSP00000455184
ENST00000568847
H3BP74 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
32 aa
3.5 kDa
No 0
ABAT-012
ENSP00000454415
ENST00000565016
H3BMJ9 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008483 [transaminase activity]
GO:0009058 [biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
91 aa
10.2 kDa
No 0
ABAT-013
ENSP00000456267
ENST00000561870
H3BRJ1 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008483 [transaminase activity]
GO:0009058 [biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
65 aa
7.3 kDa
No 0
ABAT-201
ENSP00000379845
ENST00000396600
P80404 [Direct mapping]
4-aminobutyrate aminotransferase, mitochondrial
X5D8S1 [Target identity:100%; Query identity:100%]
4-aminobutyrate aminotransferase isoform A
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0003867 [4-aminobutyrate transaminase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007568 [aging]
GO:0007620 [copulation]
GO:0007626 [locomotory behavior]
GO:0008483 [transaminase activity]
GO:0009448 [gamma-aminobutyric acid metabolic process]
GO:0009449 [gamma-aminobutyric acid biosynthetic process]
GO:0009450 [gamma-aminobutyric acid catabolic process]
GO:0010039 [response to iron ion]
GO:0014053 [negative regulation of gamma-aminobutyric acid secretion]
GO:0021549 [cerebellum development]
GO:0030170 [pyridoxal phosphate binding]
GO:0031652 [positive regulation of heat generation]
GO:0032024 [positive regulation of insulin secretion]
GO:0032144 [4-aminobutyrate transaminase complex]
GO:0032145 [succinate-semialdehyde dehydrogenase binding]
GO:0033602 [negative regulation of dopamine secretion]
GO:0035094 [response to nicotine]
GO:0035640 [exploration behavior]
GO:0042135 [neurotransmitter catabolic process]
GO:0042220 [response to cocaine]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0045471 [response to ethanol]
GO:0045776 [negative regulation of blood pressure]
GO:0045964 [positive regulation of dopamine metabolic process]
GO:0046872 [metal ion binding]
GO:0047298 [(S)-3-amino-2-methylpropionate transaminase activity]
GO:0048148 [behavioral response to cocaine]
GO:0051536 [iron-sulfur cluster binding]
GO:0070062 [extracellular exosome]
GO:0070474 [positive regulation of uterine smooth muscle contraction]
GO:0090331 [negative regulation of platelet aggregation]
GO:0097151 [positive regulation of inhibitory postsynaptic potential]
GO:1902722 [positive regulation of prolactin secretion]
GO:1904450 [positive regulation of aspartate secretion]
Show all
500 aa
56.4 kDa
No 0

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