Expression of CALN1 in cancer - Summary - The Human Protein Atlas

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CALN1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CALN1
Gene description	Calneuron 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (Karpas-707, SCLC-21H, U-2 OS)
HPA (normal tissue):	Group enriched (adrenal gland, cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in cerebral cortex and adrenal gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA036278
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036278

GENE INFORMATION
Gene name	CALN1
Synonyms
Description	Calneuron 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with high similarity to the calcium-binding proteins of the calmodulin family. The encoded protein contains two EF-hand domains and potential calcium-binding sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q11.22
Chromosome location (bp)	71779491 - 72447151
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183166 (version 83.38)
Entrez gene	83698
UniProt	Q9BXU9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BXU9
Antibodypedia	CALN1 antibodies

PROTEIN BROWSER

CALN1-004	CALN1-005	CALN1-006	CALN1-007	CALN1-008	CALN1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CALN1-004 ENSP00000332498 ENST00000329008	Q9BXU9 [Direct mapping] Calcium-binding protein 8 A4D1Z1 [Target identity:100%; Query identity:100%] Calneuron 1; cDNA FLJ41868 fis, clone OCBBF2007194, highly similar to Calneuron-1 (Calcium-binding protein CaBP8); cDNA, FLJ93531, Homo sapiens calneuron 1 (CALN1), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0032588 [trans-Golgi network membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	219 aa 24.8 kDa	No	1
CALN1-005 ENSP00000378691 ENST00000395276	Q9BXU9 [Direct mapping] Calcium-binding protein 8 A4D1Z1 [Target identity:100%; Query identity:100%] Calneuron 1; cDNA FLJ41868 fis, clone OCBBF2007194, highly similar to Calneuron-1 (Calcium-binding protein CaBP8); cDNA, FLJ93531, Homo sapiens calneuron 1 (CALN1), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0032588 [trans-Golgi network membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	219 aa 24.8 kDa	No	1
CALN1-006 ENSP00000378690 ENST00000395275	Q9BXU9 [Direct mapping] Calcium-binding protein 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0032588 [trans-Golgi network membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	261 aa 29.3 kDa	No	1
CALN1-007 ENSP00000410704 ENST00000431984	Q9BXU9 [Direct mapping] Calcium-binding protein 8 A4D1Z1 [Target identity:100%; Query identity:100%] Calneuron 1; cDNA FLJ41868 fis, clone OCBBF2007194, highly similar to Calneuron-1 (Calcium-binding protein CaBP8); cDNA, FLJ93531, Homo sapiens calneuron 1 (CALN1), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0032588 [trans-Golgi network membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	219 aa 24.8 kDa	No	1
CALN1-008 ENSP00000411806 ENST00000446128	E9PFU3 [Direct mapping] Calcium-binding protein 8 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] Show all	125 aa 14 kDa	No	0
CALN1-201 ENSP00000384354 ENST00000405452	A0A0A0MSB7 [Direct mapping] Calcium-binding protein 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	95 aa 11 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.