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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

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BCOR
  • TISSUE

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TISSUE ATLAS

GENE/PROTEIN

Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

BCOR

Gene description

BCL6 corepressor

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

11
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY

Reliability score

Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
N/A
Cerebral cortex
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Thyroid gland
N/A
Parathyroid gland
N/A
Adrenal gland
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Bone marrow
N/A
Lymph node
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Heart muscle
N/A
Skeletal muscle
N/A
Smooth muscle
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Gallbladder
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Salivary gland
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Small intestine
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
Prostate
N/A
Seminal vesicle
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
Endometrium
N/A
Fallopian tube
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Adipose tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW

Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

BCOR (HGNC Symbol)

Synonyms

FLJ20285, KIAA1575

Description

BCL6 corepressor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010]

Chromosome

X

Cytoband

p11.4

Chromosome location (bp)

40049815 - 40177329

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000183337 (version 83.38)

Entrez gene

54880

UniProt

Q6W2J9 (UniProt - Evidence at protein level)

neXtProt

NX_Q6W2J9

Antibodypedia

BCOR antibodies

PROTEIN BROWSER

«
BCOR-001
BCOR-002
BCOR-003
BCOR-004
BCOR-005
BCOR-006
BCOR-007
BCOR-008
BCOR-010
BCOR-201
BCOR-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCOR-001
ENSP00000408006
ENST00000413905
H7C2V9 [Direct mapping]
BCL-6 corepressor
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
594 aa
66.6 kDa
No 0
BCOR-002
ENSP00000403823
ENST00000427012
H7C231 [Direct mapping]
BCL-6 corepressor
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
289 aa
32.4 kDa
No 0
BCOR-003
ENSP00000367705
ENST00000378444
Q6W2J9 [Direct mapping]
BCL-6 corepressor
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000415 [negative regulation of histone H3-K36 methylation]
GO:0003714 [transcription corepressor activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0030502 [negative regulation of bone mineralization]
GO:0031072 [heat shock protein binding]
GO:0031519 [PcG protein complex]
GO:0035518 [histone H2A monoubiquitination]
GO:0042476 [odontogenesis]
GO:0042826 [histone deacetylase binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051572 [negative regulation of histone H3-K4 methylation]
GO:0060021 [palate development]
GO:0065001 [specification of axis polarity]
GO:0070171 [negative regulation of tooth mineralization]
Show all
1755 aa
192.2 kDa
No 0
BCOR-004
ENSP00000367716
ENST00000378455
Q6W2J9 [Direct mapping]
BCL-6 corepressor
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000415 [negative regulation of histone H3-K36 methylation]
GO:0003714 [transcription corepressor activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0030502 [negative regulation of bone mineralization]
GO:0031072 [heat shock protein binding]
GO:0031519 [PcG protein complex]
GO:0035518 [histone H2A monoubiquitination]
GO:0042476 [odontogenesis]
GO:0042826 [histone deacetylase binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051572 [negative regulation of histone H3-K4 methylation]
GO:0060021 [palate development]
GO:0065001 [specification of axis polarity]
GO:0070171 [negative regulation of tooth mineralization]
Show all
1703 aa
186.2 kDa
No 0
BCOR-005
ENSP00000390273
ENST00000412952
C9JHP3 [Direct mapping]
BCL-6 corepressor
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
28 aa
3.1 kDa
No 0
BCOR-006
ENSP00000384485
ENST00000406200
H7BYY2 [Direct mapping]
BCL-6 corepressor
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
1287 aa
139.1 kDa
No 0
BCOR-007
ENSP00000380512
ENST00000397354
Q6W2J9 [Direct mapping]
BCL-6 corepressor
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000415 [negative regulation of histone H3-K36 methylation]
GO:0003714 [transcription corepressor activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0030502 [negative regulation of bone mineralization]
GO:0031072 [heat shock protein binding]
GO:0031519 [PcG protein complex]
GO:0035518 [histone H2A monoubiquitination]
GO:0042476 [odontogenesis]
GO:0042826 [histone deacetylase binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051572 [negative regulation of histone H3-K4 methylation]
GO:0060021 [palate development]
GO:0065001 [specification of axis polarity]
GO:0070171 [negative regulation of tooth mineralization]
Show all
1721 aa
188.2 kDa
No 0
BCOR-008
ENSP00000367724
ENST00000378463
A6NE70 [Direct mapping]
BCL-6 corepressor
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
622 aa
69.7 kDa
No 0
BCOR-010
ENSP00000387552
ENST00000442018
H7BZ37 [Direct mapping]
BCL-6 corepressor
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
332 aa
37.3 kDa
No 0
BCOR-201
ENSP00000345923
ENST00000342274
Q6W2J9 [Direct mapping]
BCL-6 corepressor
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000415 [negative regulation of histone H3-K36 methylation]
GO:0003714 [transcription corepressor activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0030502 [negative regulation of bone mineralization]
GO:0031072 [heat shock protein binding]
GO:0031519 [PcG protein complex]
GO:0035518 [histone H2A monoubiquitination]
GO:0042476 [odontogenesis]
GO:0042826 [histone deacetylase binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051572 [negative regulation of histone H3-K4 methylation]
GO:0060021 [palate development]
GO:0065001 [specification of axis polarity]
GO:0070171 [negative regulation of tooth mineralization]
Show all
1721 aa
188.2 kDa
No 0
BCOR-202
ENSP00000483217
ENST00000615339
A1A564 [Direct mapping]
BCL-6 corepressor; BCOR protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
411 aa
44.7 kDa
No 0

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