Cell atlas - BCOR - The Human Protein Atlas

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BCOR

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	BCOR
Gene description	BCL6 corepressor
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA056308 , HPA066234
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056308	HEK 293	Nucleus
	HPA056308	PC-3	Nucleus
	HPA056308	U-2 OS	Nucleus
	HPA066234	SH-SY5Y	Nucleoplasm
	HPA066234	U-2 OS	Nucleus

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000040363 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA056308	NIH 3T3	No staining

GENE INFORMATION
Gene name	BCOR (HGNC Symbol)
Synonyms	FLJ20285, KIAA1575
Description	BCL6 corepressor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010]
Chromosome	X
Cytoband	p11.4
Chromosome location (bp)	40049815 - 40177329
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183337 (version 83.38)
Entrez gene	54880
UniProt	Q6W2J9 (UniProt - Evidence at protein level)
neXtProt	NX_Q6W2J9
Antibodypedia	BCOR antibodies

PROTEIN BROWSER

BCOR-001	BCOR-002	BCOR-003	BCOR-004	BCOR-005	BCOR-006	BCOR-007	BCOR-008	BCOR-010	BCOR-201	BCOR-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCOR-001 ENSP00000408006 ENST00000413905	H7C2V9 [Direct mapping] BCL-6 corepressor Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	594 aa 66.6 kDa	No	0
BCOR-002 ENSP00000403823 ENST00000427012	H7C231 [Direct mapping] BCL-6 corepressor Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	289 aa 32.4 kDa	No	0
BCOR-003 ENSP00000367705 ENST00000378444	Q6W2J9 [Direct mapping] BCL-6 corepressor Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000415 [negative regulation of histone H3-K36 methylation] GO:0003714 [transcription corepressor activity] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0007507 [heart development] GO:0008134 [transcription factor binding] GO:0030502 [negative regulation of bone mineralization] GO:0031072 [heat shock protein binding] GO:0031519 [PcG protein complex] GO:0035518 [histone H2A monoubiquitination] GO:0042476 [odontogenesis] GO:0042826 [histone deacetylase binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0051572 [negative regulation of histone H3-K4 methylation] GO:0060021 [palate development] GO:0065001 [specification of axis polarity] GO:0070171 [negative regulation of tooth mineralization] Show all	1755 aa 192.2 kDa	No	0
BCOR-004 ENSP00000367716 ENST00000378455	Q6W2J9 [Direct mapping] BCL-6 corepressor Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000415 [negative regulation of histone H3-K36 methylation] GO:0003714 [transcription corepressor activity] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0007507 [heart development] GO:0008134 [transcription factor binding] GO:0030502 [negative regulation of bone mineralization] GO:0031072 [heat shock protein binding] GO:0031519 [PcG protein complex] GO:0035518 [histone H2A monoubiquitination] GO:0042476 [odontogenesis] GO:0042826 [histone deacetylase binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0051572 [negative regulation of histone H3-K4 methylation] GO:0060021 [palate development] GO:0065001 [specification of axis polarity] GO:0070171 [negative regulation of tooth mineralization] Show all	1703 aa 186.2 kDa	No	0
BCOR-005 ENSP00000390273 ENST00000412952	C9JHP3 [Direct mapping] BCL-6 corepressor Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		28 aa 3.1 kDa	No	0
BCOR-006 ENSP00000384485 ENST00000406200	H7BYY2 [Direct mapping] BCL-6 corepressor Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		1287 aa 139.1 kDa	No	0
BCOR-007 ENSP00000380512 ENST00000397354	Q6W2J9 [Direct mapping] BCL-6 corepressor Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000415 [negative regulation of histone H3-K36 methylation] GO:0003714 [transcription corepressor activity] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0007507 [heart development] GO:0008134 [transcription factor binding] GO:0030502 [negative regulation of bone mineralization] GO:0031072 [heat shock protein binding] GO:0031519 [PcG protein complex] GO:0035518 [histone H2A monoubiquitination] GO:0042476 [odontogenesis] GO:0042826 [histone deacetylase binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0051572 [negative regulation of histone H3-K4 methylation] GO:0060021 [palate development] GO:0065001 [specification of axis polarity] GO:0070171 [negative regulation of tooth mineralization] Show all	1721 aa 188.2 kDa	No	0
BCOR-008 ENSP00000367724 ENST00000378463	A6NE70 [Direct mapping] BCL-6 corepressor Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	622 aa 69.7 kDa	No	0
BCOR-010 ENSP00000387552 ENST00000442018	H7BZ37 [Direct mapping] BCL-6 corepressor Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	332 aa 37.3 kDa	No	0
BCOR-201 ENSP00000345923 ENST00000342274	Q6W2J9 [Direct mapping] BCL-6 corepressor Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000415 [negative regulation of histone H3-K36 methylation] GO:0003714 [transcription corepressor activity] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0007507 [heart development] GO:0008134 [transcription factor binding] GO:0030502 [negative regulation of bone mineralization] GO:0031072 [heat shock protein binding] GO:0031519 [PcG protein complex] GO:0035518 [histone H2A monoubiquitination] GO:0042476 [odontogenesis] GO:0042826 [histone deacetylase binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0051572 [negative regulation of histone H3-K4 methylation] GO:0060021 [palate development] GO:0065001 [specification of axis polarity] GO:0070171 [negative regulation of tooth mineralization] Show all	1721 aa 188.2 kDa	No	0
BCOR-202 ENSP00000483217 ENST00000615339	A1A564 [Direct mapping] BCL-6 corepressor; BCOR protein Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		411 aa 44.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.