Fields »
ABOUT
HELP
BLOG
SF3A3

GENERAL INFORMATION

Gene name

 SF3A3

Gene description

 Splicing factor 3a, subunit 3, 60kDa

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending retesting.

Reliability score

 Supported based on 2 antibodies.
HPA032054 , HPA032055
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA032054
HPA032055

GENE INFORMATION

Gene name

 SF3A3 (HGNC Symbol)

Synonyms

 PRP9, PRPF9, SAP61, SF3a60

Description

 Splicing factor 3a, subunit 3, 60kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p34.3

Chromosome location (bp)

 37956975 - 37990921

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183431 (version 83.38)

Entrez gene

 10946

UniProt

 Q12874 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12874

Antibodypedia

 SF3A3 antibodies

PROTEIN BROWSER
SF3A3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SF3A3-001
ENSP00000362110
ENST00000373019
Q12874 [Direct mapping]
Splicing factor 3A subunit 3
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000389 [mRNA 3'-splice site recognition]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0006397 [mRNA processing]
GO:0008270 [zinc ion binding]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 501 aa
58.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.