Cell atlas - ASB7 - The Human Protein Atlas

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ASB7

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Nucleus
	Vesicles

Human cell
	Golgi Apparatus
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	ASB7
Gene description	Ankyrin repeat and SOCS box containing 7
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus & vesicles. In addition localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved), Vesicles (approved)
Additional location	In addition localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA003300
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus & vesicles. In addition localized to the nucleus.

Main location

Golgi apparatus (approved), Vesicles (approved)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA003300	A-431	Golgi apparatus
	HPA003300	A-431	Cytosol
	HPA003300	U-2 OS	Vesicles
	HPA003300	U-251 MG	Nucleus
	HPA003300	U-251 MG	Golgi apparatus

GENE INFORMATION
Gene name	ASB7
Synonyms
Description	Ankyrin repeat and SOCS box containing 7 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q26.3
Chromosome location (bp)	100602534 - 100651705
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183475 (version 83.38)
Entrez gene	140460
UniProt	Q9H672 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H672
Antibodypedia	ASB7 antibodies

PROTEIN BROWSER

ASB7-001	ASB7-002	ASB7-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASB7-001 ENSP00000328327 ENST00000332783	Q9H672 [Direct mapping] Ankyrin repeat and SOCS box protein 7 A0A024RC94 [Target identity:100%; Query identity:100%] Ankyrin repeat and SOCS box-containing 7, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0016567 [protein ubiquitination] GO:0035556 [intracellular signal transduction] Show all	318 aa 36 kDa	No	0
ASB7-002 ENSP00000339819 ENST00000343276	Q9H672 [Direct mapping] Ankyrin repeat and SOCS box protein 7 A0A024RCD9 [Target identity:100%; Query identity:100%] Ankyrin repeat and SOCS box-containing 7, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0016567 [protein ubiquitination] GO:0035556 [intracellular signal transduction] Show all	274 aa 30.7 kDa	No	0
ASB7-003 ENSP00000453626 ENST00000558747	H0YMJ1 [Direct mapping] Ankyrin repeat and SOCS box protein 7 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0016567 [protein ubiquitination] GO:0035556 [intracellular signal transduction] Show all	116 aa 13.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.