Expression of ASB7 in cancer - Summary - The Human Protein Atlas

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ASB7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ASB7
Gene description	Ankyrin repeat and SOCS box containing 7
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA003300
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003300

GENE INFORMATION
Gene name	ASB7
Synonyms
Description	Ankyrin repeat and SOCS box containing 7 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q26.3
Chromosome location (bp)	100602534 - 100651705
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183475 (version 83.38)
Entrez gene	140460
UniProt	Q9H672 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H672
Antibodypedia	ASB7 antibodies

PROTEIN BROWSER

ASB7-001	ASB7-002	ASB7-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASB7-001 ENSP00000328327 ENST00000332783	Q9H672 [Direct mapping] Ankyrin repeat and SOCS box protein 7 A0A024RC94 [Target identity:100%; Query identity:100%] Ankyrin repeat and SOCS box-containing 7, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0016567 [protein ubiquitination] GO:0035556 [intracellular signal transduction] Show all	318 aa 36 kDa	No	0
ASB7-002 ENSP00000339819 ENST00000343276	Q9H672 [Direct mapping] Ankyrin repeat and SOCS box protein 7 A0A024RCD9 [Target identity:100%; Query identity:100%] Ankyrin repeat and SOCS box-containing 7, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0016567 [protein ubiquitination] GO:0035556 [intracellular signal transduction] Show all	274 aa 30.7 kDa	No	0
ASB7-003 ENSP00000453626 ENST00000558747	H0YMJ1 [Direct mapping] Ankyrin repeat and SOCS box protein 7 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0016567 [protein ubiquitination] GO:0035556 [intracellular signal transduction] Show all	116 aa 13.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.