Expression of FAM19A1 in cancer - Summary - The Human Protein Atlas

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FAM19A1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM19A1
Gene description	Family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enriched (REH)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, distinct expression in the brain.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. HPA013407
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA013407

GENE INFORMATION
Gene name	FAM19A1 (HGNC Symbol)
Synonyms	TAFA-1
Description	Family with sequence similarity 19 (chemokine (C-C motif)-like), member A1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p14.1
Chromosome location (bp)	68004216 - 68545625
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183662 (version 83.38)
Entrez gene	407738
UniProt	Q7Z5A9 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z5A9
Antibodypedia	FAM19A1 antibodies

PROTEIN BROWSER

FAM19A1-001	FAM19A1-002	FAM19A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM19A1-001 ENSP00000418575 ENST00000478136	Q7Z5A9 [Direct mapping] Protein FAM19A1 Show all	MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005783 [endoplasmic reticulum] Show all	133 aa 14.9 kDa	Yes	0
FAM19A1-002 ENSP00000417496 ENST00000496687	Q7Z5A9 [Direct mapping] Protein FAM19A1 Show all	MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005783 [endoplasmic reticulum] Show all	133 aa 14.9 kDa	Yes	0
FAM19A1-201 ENSP00000485030 ENST00000617084	A0A087X2J7 [Direct mapping] Protein FAM19A1 Show all	Predicted intracellular proteins Show all		52 aa 5.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.