Expression of TRMT12 in cancer - Summary - The Human Protein Atlas

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TRMT12

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TRMT12
Gene description	TRNA methyltransferase 12 homolog (S. cerevisiae)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (MCF7)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA023939
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable), liver cancer (unfavourable) and thyroid cancer (unfavourable).
Head and neck cancer p<0.001 Liver cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA023939

GENE INFORMATION
Gene name	TRMT12 (HGNC Symbol)
Synonyms	FLJ20772, Trm12, TYW2
Description	TRNA methyltransferase 12 homolog (S. cerevisiae) (HGNC Symbol)
Entrez gene summary	Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]
Chromosome	8
Cytoband	q24.13
Chromosome location (bp)	124450820 - 124462150
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183665 (version 83.38)
Entrez gene	55039
UniProt	Q53H54 (UniProt - Evidence at protein level)
neXtProt	NX_Q53H54
Antibodypedia	TRMT12 antibodies

PROTEIN BROWSER

TRMT12-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRMT12-001 ENSP00000329858 ENST00000328599	Q53H54 [Direct mapping] tRNA wybutosine-synthesizing protein 2 homolog Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0010467 [gene expression] GO:0016740 [transferase activity] Show all	448 aa 50.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.