Cell atlas - IFNL2 - The Human Protein Atlas

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IFNL2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	IFNL2
Gene description	Interferon, lambda 2
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (HDLM-2)
Protein evidence	Evidence at transcript level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HDLM-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	IFNL2 (HGNC Symbol)
Synonyms	IL-28A, IL28A
Description	Interferon, lambda 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	39268514 - 39270092
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000183709 (version 83.38)
Entrez gene	282616
UniProt	Q8IZJ0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8IZJ0
Antibodypedia	IFNL2 antibodies

PROTEIN BROWSER

IFNL2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IFNL2-001 ENSP00000333639 ENST00000331982	Q8IZJ0 [Direct mapping] Interferon lambda-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0002385 [mucosal immune response] GO:0005102 [receptor binding] GO:0005125 [cytokine activity] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0007259 [JAK-STAT cascade] GO:0045087 [innate immune response] GO:0050778 [positive regulation of immune response] GO:0050863 [regulation of T cell activation] GO:0051607 [defense response to virus] Show all	200 aa 22.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.