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IFNL2

GENERAL INFORMATION

Gene name

 IFNL2

Gene description

 Interferon, lambda 2

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enriched (HDLM-2)
HPA (normal tissue):Not detected

Protein evidence

 Evidence at transcript level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. No RNA expression data detected and pending external verification.

Reliability score

 Uncertain based on 1 antibody.
CAB025489
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB025489

GENE INFORMATION

Gene name

 IFNL2 (HGNC Symbol)

Synonyms

 IL-28A, IL28A

Description

 Interferon, lambda 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 39268514 - 39270092

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000183709 (version 83.38)

Entrez gene

 282616

UniProt

 Q8IZJ0 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8IZJ0

Antibodypedia

 IFNL2 antibodies

PROTEIN BROWSER
IFNL2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IFNL2-001
ENSP00000333639
ENST00000331982
Q8IZJ0 [Direct mapping]
Interferon lambda-2
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0002385 [mucosal immune response]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0007259 [JAK-STAT cascade]
GO:0045087 [innate immune response]
GO:0050778 [positive regulation of immune response]
GO:0050863 [regulation of T cell activation]
GO:0051607 [defense response to virus]
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 200 aa
22.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.