Expression of CMTM4 in cancer - Summary

GENERAL INFORMATION
Gene name	CMTM4
Gene description	CKLF-like MARVEL transmembrane domain containing 4
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression, most abundant in thryoid and parathyroid glands.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA014704 , HPA023890
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA014704	HPA023890

GENE INFORMATION
Gene name	CMTM4 (HGNC Symbol)
Synonyms	CKLFSF4
Description	CKLF-like MARVEL transmembrane domain containing 4 (HGNC Symbol)
Entrez gene summary	This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	66614750 - 66696707
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183723 (version 83.38)
Entrez gene	146223
UniProt	Q8IZR5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZR5
Antibodypedia	CMTM4 antibodies

PROTEIN BROWSER

CMTM4-001	CMTM4-002	CMTM4-003	CMTM4-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CMTM4-001 ENSP00000333833 ENST00000330687	Q8IZR5 [Direct mapping] CKLF-like MARVEL transmembrane domain-containing protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005125 [cytokine activity] GO:0005615 [extracellular space] GO:0006935 [chemotaxis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	234 aa 25.8 kDa	No	4
CMTM4-002 ENSP00000377666 ENST00000394106	Q8IZR5 [Direct mapping] CKLF-like MARVEL transmembrane domain-containing protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005125 [cytokine activity] GO:0005615 [extracellular space] GO:0006935 [chemotaxis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	208 aa 22.8 kDa	No	4
CMTM4-003 ENSP00000456380 ENST00000563952	Q8IZR5 [Direct mapping] CKLF-like MARVEL transmembrane domain-containing protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005125 [cytokine activity] GO:0005615 [extracellular space] GO:0006935 [chemotaxis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	179 aa 19.7 kDa	No	3
CMTM4-004 ENSP00000464316 ENST00000561680	J3QRP2 [Direct mapping] CKLF-like MARVEL transmembrane domain-containing protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	140 aa 15.8 kDa	No	2