Expression of ACSM2A in cancer - Summary - The Human Protein Atlas

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ACSM2A

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACSM2A
Gene description	Acyl-CoA synthetase medium-chain family member 2A
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (liver cancer, renal cancer)
HPA (cell line):	Cell line enhanced (Hep G2)
HPA (normal tissue):	Group enriched (kidney, liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in liver and kidney

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 1 antibody. HPA057699
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (liver cancer, renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA057699

GENE INFORMATION
Gene name	ACSM2A (HGNC Symbol)
Synonyms	A-923A4.1, ACSM2, MGC150530
Description	Acyl-CoA synthetase medium-chain family member 2A (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p12.3
Chromosome location (bp)	20451461 - 20487667
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183747 (version 83.38)
Entrez gene	123876
UniProt	Q08AH3 (UniProt - Evidence at protein level)
neXtProt	NX_Q08AH3
Antibodypedia	ACSM2A antibodies

PROTEIN BROWSER

ACSM2A-001	ACSM2A-003	ACSM2A-006	ACSM2A-007	ACSM2A-011	ACSM2A-012	ACSM2A-014	ACSM2A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACSM2A-001 ENSP00000459451 ENST00000573854	Q08AH3 [Direct mapping] Acyl-coenzyme A synthetase ACSM2A, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006631 [fatty acid metabolic process] GO:0008152 [metabolic process] GO:0036112 [medium-chain fatty-acyl-CoA metabolic process] GO:0042593 [glucose homeostasis] GO:0046872 [metal ion binding] GO:0047760 [butyrate-CoA ligase activity] GO:0070328 [triglyceride homeostasis] Show all	577 aa 64.2 kDa	No	2
ACSM2A-003 ENSP00000392169 ENST00000417235	F5GWL3 [Direct mapping] Acyl-coenzyme A synthetase ACSM2A, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	498 aa 55.1 kDa	No	2
ACSM2A-006 ENSP00000219054 ENST00000219054	Q08AH3 [Direct mapping] Acyl-coenzyme A synthetase ACSM2A, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006631 [fatty acid metabolic process] GO:0008152 [metabolic process] GO:0036112 [medium-chain fatty-acyl-CoA metabolic process] GO:0042593 [glucose homeostasis] GO:0046872 [metal ion binding] GO:0047760 [butyrate-CoA ligase activity] GO:0070328 [triglyceride homeostasis] Show all	577 aa 64.2 kDa	No	2
ACSM2A-007 ENSP00000460349 ENST00000575690	Q08AH3 [Direct mapping] Acyl-coenzyme A synthetase ACSM2A, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006631 [fatty acid metabolic process] GO:0008152 [metabolic process] GO:0036112 [medium-chain fatty-acyl-CoA metabolic process] GO:0042593 [glucose homeostasis] GO:0046872 [metal ion binding] GO:0047760 [butyrate-CoA ligase activity] GO:0070328 [triglyceride homeostasis] Show all	577 aa 64.2 kDa	No	2
ACSM2A-011 ENSP00000460153 ENST00000574251	I3L339 [Direct mapping] Acyl-coenzyme A synthetase ACSM2A, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	61 aa 6.8 kDa	No	1
ACSM2A-012 ENSP00000460948 ENST00000576361	I3L438 [Direct mapping] Acyl-coenzyme A synthetase ACSM2A, mitochondrial Show all	Predicted intracellular proteins Show all		106 aa 12.1 kDa	No	0
ACSM2A-014 ENSP00000460031 ENST00000571894	I3L2Y5 [Direct mapping] Acyl-coenzyme A synthetase ACSM2A, mitochondrial Show all	Predicted intracellular proteins Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	118 aa 13.4 kDa	No	0
ACSM2A-201 ENSP00000379411 ENST00000396104	Q08AH3 [Direct mapping] Acyl-coenzyme A synthetase ACSM2A, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006631 [fatty acid metabolic process] GO:0008152 [metabolic process] GO:0036112 [medium-chain fatty-acyl-CoA metabolic process] GO:0042593 [glucose homeostasis] GO:0046872 [metal ion binding] GO:0047760 [butyrate-CoA ligase activity] GO:0070328 [triglyceride homeostasis] Show all	577 aa 64.2 kDa	No	2

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The Project

The Human Protein Atlas

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