Expression of PAPL in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PAPL
Gene description	Iron/zinc purple acid phosphatase-like protein
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (cervical cancer, head and neck cancer, lung cancer, melanoma, urothelial cancer)
HPA (cell line):	Cell line enriched (U-87 MG)
HPA (normal tissue):	Group enriched (cerebral cortex, skin, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a few tissues, mainly in a subset of neuronal cells, thyroid and adrenal gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 2 antibodies. HPA042005 , HPA042613
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (cervical cancer, head and neck cancer, lung cancer, melanoma, urothelial cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA042005	HPA042613

GENE INFORMATION
Gene name	PAPL
Synonyms
Description	Iron/zinc purple acid phosphatase-like protein (UniProtKB/Swiss-Prot)
Entrez gene summary	Purple acid phosphatases (PAPs), including PAPL, are a family of binuclear metallohydrolases that have been identified in plants, animals, and fungi (Flanagan et al., 2006 [PubMed 16793224]).[supplied by OMIM, Mar 2008]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	39083913 - 39111493
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183760 (version 83.38)
Entrez gene	390928
UniProt	Q6ZNF0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6ZNF0
Antibodypedia	PAPL antibodies

PROTEIN BROWSER

PAPL-001	PAPL-003	PAPL-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAPL-001 ENSP00000327557 ENST00000331256	Q6ZNF0 [Target identity:100%; Query identity:100%] Iron/zinc purple acid phosphatase-like protein Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0005576 [extracellular region] GO:0016311 [dephosphorylation] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] Show all	438 aa 50.5 kDa	Yes	0
PAPL-003 ENSP00000470989 ENST00000594229	M0R045 [Direct mapping] Iron/zinc purple acid phosphatase-like protein Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0016311 [dephosphorylation] GO:0046872 [metal ion binding] Show all	334 aa 36.6 kDa	Yes	0
PAPL-004 ENSP00000470089 ENST00000601531	M0QYV2 [Direct mapping] Iron/zinc purple acid phosphatase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	227 aa 26.7 kDa	No	0