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PAPL

GENERAL INFORMATION

Gene name

 PAPL

Gene description

 Iron/zinc purple acid phosphatase-like protein

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cerebral cortex, skin, tonsil)
GTEx:Group enriched (cerebellum, skin)
FANTOM5:Tissue enriched (cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a few tissues, mainly in a subset of neuronal cells, thyroid and adrenal gland.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Uncertain based on 2 antibodies.
HPA042005 , HPA042613
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, skin, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebellum, skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebellum)

GENE INFORMATION

Gene name

 PAPL

Synonyms

Description

 Iron/zinc purple acid phosphatase-like protein (UniProtKB/Swiss-Prot)

Entrez gene summary

 Purple acid phosphatases (PAPs), including PAPL, are a family of binuclear metallohydrolases that have been identified in plants, animals, and fungi (Flanagan et al., 2006 [PubMed 16793224]).[supplied by OMIM, Mar 2008]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 39083913 - 39111493

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183760 (version 83.38)

Entrez gene

 390928

UniProt

 Q6ZNF0 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q6ZNF0

Antibodypedia

 PAPL antibodies

PROTEIN BROWSER
PAPL-001
PAPL-003
PAPL-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAPL-001
ENSP00000327557
ENST00000331256
Q6ZNF0 [Target identity:100%; Query identity:100%]
Iron/zinc purple acid phosphatase-like protein
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Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003993 [acid phosphatase activity]
GO:0005576 [extracellular region]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0046872 [metal ion binding]
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 438 aa
50.5 kDa 		Yes 0
PAPL-003
ENSP00000470989
ENST00000594229
M0R045 [Direct mapping]
Iron/zinc purple acid phosphatase-like protein
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   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003993 [acid phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0046872 [metal ion binding]
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 334 aa
36.6 kDa 		Yes 0
PAPL-004
ENSP00000470089
ENST00000601531
M0QYV2 [Direct mapping]
Iron/zinc purple acid phosphatase-like protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
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 227 aa
26.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.