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CNGA2

GENERAL INFORMATION

Gene name

 CNGA2

Gene description

 Cyclic nucleotide gated channel alpha 2

Protein class

 Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Not detected

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. No RNA expression data detected and pending external verification. Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA015065
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA015065

GENE INFORMATION

Gene name

 CNGA2 (HGNC Symbol)

Synonyms

 CNCA, CNCA1, CNG2, FLJ46312, OCNC1, OCNCa, OCNCALPHA

Description

 Cyclic nucleotide gated channel alpha 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 151738451 - 151745304

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183862 (version 83.38)

Entrez gene

 1260

UniProt

 Q16280 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q16280

Antibodypedia

 CNGA2 antibodies

PROTEIN BROWSER
CNGA2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNGA2-001
ENSP00000328478
ENST00000329903
Q16280 [Direct mapping]
Cyclic nucleotide-gated olfactory channel
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Voltage-gated ion channels
   Cyclic Nucleotide-Regulated Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0000139 [Golgi membrane]
GO:0005216 [ion channel activity]
GO:0005222 [intracellular cAMP activated cation channel activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005516 [calmodulin binding]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006996 [organelle organization]
GO:0007608 [sensory perception of smell]
GO:0016020 [membrane]
GO:0030552 [cAMP binding]
GO:0030553 [cGMP binding]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0042391 [regulation of membrane potential]
GO:0050896 [response to stimulus]
GO:0055085 [transmembrane transport]
GO:0060170 [ciliary membrane]
GO:0071805 [potassium ion transmembrane transport]
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 664 aa
76 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.