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Several case of colorectal cancer and hepatocellular carcinomas showed moderate to strong cytoplasmic positivity often with a granular pattern. Most remaining cancer tissues were weakly stained or negative.
Moderate to strong cytoplasmic immunoreactivity in most adenocarcinomas. The particular pattern of dot-like staining in golgi region was observed in a majority of adenocarcinomas and in single cases of hepatocellular- and cholangiocarcinomas. Most renal cell carcinomas, skin cancers, lung cancers and lymphomas were negative.
GENE INFORMATION
Gene name
PTP4A2 (HGNC Symbol)
Synonyms
HU-PP-1, OV-1, PRL-2, ptp-IV1a, PTP4A, PTPCAAX2
Description
Protein tyrosine phosphatase type IVA, member 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
Q12974 [Direct mapping] Protein tyrosine phosphatase type IVA 2
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Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q12974 [Direct mapping] Protein tyrosine phosphatase type IVA 2
Show all
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)