Cell atlas - CLDN5 - The Human Protein Atlas

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CLDN5

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CLDN5
Gene description	Claudin 5
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (HUVEC TERT2, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HUVEC TERT2, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CLDN5 (HGNC Symbol)
Synonyms	AWAL, BEC1, CPETRL1, TMVCF
Description	Claudin 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008]
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	19523024 - 19527545
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184113 (version 83.38)
Entrez gene	7122
UniProt	O00501 (UniProt - Evidence at transcript level)
neXtProt	NX_O00501
Antibodypedia	CLDN5 antibodies

PROTEIN BROWSER

CLDN5-001	CLDN5-002	CLDN5-003	CLDN5-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLDN5-001 ENSP00000385477 ENST00000406028	D3DX19 [Direct mapping] Claudin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] GO:0033270 [paranode region of axon] GO:0042552 [myelination] GO:0043220 [Schmidt-Lanterman incisure] Show all	303 aa 31.6 kDa	No	4
CLDN5-002 ENSP00000400612 ENST00000413119	D3DX19 [Direct mapping] Claudin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] Show all	303 aa 31.6 kDa	No	4
CLDN5-003 ENSP00000384554 ENST00000403084	D3DX19 [Direct mapping] Claudin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] Show all	303 aa 31.6 kDa	No	4
CLDN5-004 ENSP00000480623 ENST00000618236	O00501 [Direct mapping] Claudin-5 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0003151 [outflow tract morphogenesis] GO:0005198 [structural molecule activity] GO:0005911 [cell-cell junction] GO:0005923 [bicellular tight junction] GO:0007043 [cell-cell junction assembly] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007612 [learning] GO:0016021 [integral component of membrane] GO:0016327 [apicolateral plasma membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0030864 [cortical actin cytoskeleton] GO:0042802 [identical protein binding] GO:0060021 [palate development] GO:0060325 [face morphogenesis] GO:0070062 [extracellular exosome] GO:1903142 [positive regulation of establishment of endothelial barrier] Show all	218 aa 23.1 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.