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A majority of adenocarcinomas and a few squamous cell carcinomas showed moderate to strong cytoplasmic and membranous immunoreactivity. Remaining tumors were in general negative.
GENE INFORMATION
Gene name
CLDN5 (HGNC Symbol)
Synonyms
AWAL, BEC1, CPETRL1, TMVCF
Description
Claudin 5 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008]