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KCNQ3

GENERAL INFORMATION

Gene name

 KCNQ3

Gene description

 Potassium channel, voltage gated KQT-like subfamily Q, member 3

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (RPMI-8226, SCLC-21H, U-2 OS, U-87 MG)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 KCNQ3 (HGNC Symbol)

Synonyms

 EBN2, Kv7.3

Description

 Potassium channel, voltage gated KQT-like subfamily Q, member 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that functions in the regulation of neuronal excitability. The encoded protein forms an M-channel by associating with the products of the related KCNQ2 or KCNQ5 genes, which both encode integral membrane proteins. M-channel currents are inhibited by M1 muscarinic acetylcholine receptors and are activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

Chromosome

 8

Cytoband

 q24.22

Chromosome location (bp)

 132120859 - 132480953

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184156 (version 83.38)

Entrez gene

 3786

UniProt

 O43525 (UniProt - Evidence at protein level)

neXtProt

 NX_O43525

Antibodypedia

 KCNQ3 antibodies

PROTEIN BROWSER
KCNQ3-001
KCNQ3-002
KCNQ3-004
KCNQ3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNQ3-001
ENSP00000373648
ENST00000388996
O43525 [Direct mapping]
Potassium voltage-gated channel subfamily KQT member 3
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005216 [ion channel activity]
GO:0005244 [voltage-gated ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005267 [potassium channel activity]
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0033268 [node of Ranvier]
GO:0034765 [regulation of ion transmembrane transport]
GO:0043194 [axon initial segment]
GO:0055085 [transmembrane transport]
GO:0060081 [membrane hyperpolarization]
GO:0071805 [potassium ion transmembrane transport]
Show all
 872 aa
96.7 kDa 		No 5
KCNQ3-002
ENSP00000428790
ENST00000519445
E7ET42 [Direct mapping]
Potassium voltage-gated channel subfamily KQT member 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005267 [potassium channel activity]
GO:0006811 [ion transport]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
Show all
 860 aa
95.4 kDa 		No 5
KCNQ3-004
ENSP00000429799
ENST00000521134
O43525 [Direct mapping]
Potassium voltage-gated channel subfamily KQT member 3
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005267 [potassium channel activity]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0033268 [node of Ranvier]
GO:0034765 [regulation of ion transmembrane transport]
GO:0043194 [axon initial segment]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
Show all
 752 aa
84.8 kDa 		Yes 4
KCNQ3-201
ENSP00000482510
ENST00000621976
A0A087WZB4 [Direct mapping]
Potassium voltage-gated channel subfamily KQT member 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005267 [potassium channel activity]
GO:0006811 [ion transport]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
Show all
 751 aa
84.7 kDa 		Yes 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.