Tissue expression of KCNQ3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KCNQ3
Gene description	Potassium channel, voltage gated KQT-like subfamily Q, member 3
Protein class	Disease related genes FDA approved drug targets Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Tissue enhanced (caudate, cerebral cortex)
FANTOM5:	Group enriched (brain, caudate, hippocampus)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate, cerebral cortex)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (brain, caudate, hippocampus)

GENE INFORMATION
Gene name	KCNQ3 (HGNC Symbol)
Synonyms	EBN2, Kv7.3
Description	Potassium channel, voltage gated KQT-like subfamily Q, member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that functions in the regulation of neuronal excitability. The encoded protein forms an M-channel by associating with the products of the related KCNQ2 or KCNQ5 genes, which both encode integral membrane proteins. M-channel currents are inhibited by M1 muscarinic acetylcholine receptors and are activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Chromosome	8
Cytoband	q24.22
Chromosome location (bp)	132120859 - 132480953
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184156 (version 83.38)
Entrez gene	3786
UniProt	O43525 (UniProt - Evidence at protein level)
neXtProt	NX_O43525
Antibodypedia	KCNQ3 antibodies

PROTEIN BROWSER

KCNQ3-001	KCNQ3-002	KCNQ3-004	KCNQ3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNQ3-001 ENSP00000373648 ENST00000388996	O43525 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 3 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005267 [potassium channel activity] GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0008076 [voltage-gated potassium channel complex] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0033268 [node of Ranvier] GO:0034765 [regulation of ion transmembrane transport] GO:0043194 [axon initial segment] GO:0055085 [transmembrane transport] GO:0060081 [membrane hyperpolarization] GO:0071805 [potassium ion transmembrane transport] Show all	872 aa 96.7 kDa	No	5
KCNQ3-002 ENSP00000428790 ENST00000519445	E7ET42 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005267 [potassium channel activity] GO:0006811 [ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	860 aa 95.4 kDa	No	5
KCNQ3-004 ENSP00000429799 ENST00000521134	O43525 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 3 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0033268 [node of Ranvier] GO:0034765 [regulation of ion transmembrane transport] GO:0043194 [axon initial segment] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	752 aa 84.8 kDa	Yes	4
KCNQ3-201 ENSP00000482510 ENST00000621976	A0A087WZB4 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005267 [potassium channel activity] GO:0006811 [ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	751 aa 84.7 kDa	Yes	4