Cell atlas - KCNJ12 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KCNJ12
Gene description	Potassium channel, inwardly rectifying subfamily J, member 12
Protein class	FDA approved drug targets Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus. In addition localized to the cytosol & nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (SCLC-21H, U-2197, PC-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (uncertain)
Additional location	In addition localized to the Nucleoplasm (uncertain), Cytosol (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA027021
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, U-2197, PC-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus. In addition localized to the cytosol & nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Golgi apparatus (uncertain)

Additional location

Nucleoplasm (uncertain), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA027021	PC-3	Nucleoplasm	Intensity
		Golgi apparatus
		Cytosol
HPA027021	U-2 OS	Golgi apparatus
HPA027021	U-251 MG	Nucleoplasm
		Golgi apparatus
		Cytosol

GENE INFORMATION
Gene name	KCNJ12 (HGNC Symbol)
Synonyms	hIRK1, IRK2, KCNJN1, Kir2.2, Kir2.2v
Description	Potassium channel, inwardly rectifying subfamily J, member 12 (HGNC Symbol)
Entrez gene summary	This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	21376197 - 21419872
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184185 (version 83.38)
Entrez gene	3768
UniProt	Q14500 (UniProt - Evidence at protein level)
neXtProt	NX_Q14500
Antibodypedia	KCNJ12 antibodies

PROTEIN BROWSER

KCNJ12-001	KCNJ12-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNJ12-001 ENSP00000463778 ENST00000583088	Q14500 [Direct mapping] ATP-sensitive inward rectifier potassium channel 12 Show all	Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0006936 [muscle contraction] GO:0007268 [synaptic transmission] GO:0008016 [regulation of heart contraction] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0031224 [intrinsic component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0051289 [protein homotetramerization] Show all	433 aa 49 kDa	No	3
KCNJ12-002 ENSP00000328150 ENST00000331718	Q14500 [Direct mapping] ATP-sensitive inward rectifier potassium channel 12 Show all	Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0006936 [muscle contraction] GO:0007268 [synaptic transmission] GO:0008016 [regulation of heart contraction] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0031224 [intrinsic component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0051289 [protein homotetramerization] Show all	433 aa 49 kDa	No	3