Expression of KCNJ12 in cancer - Summary - The Human Protein Atlas

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KCNJ12

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KCNJ12
Gene description	Potassium channel, inwardly rectifying subfamily J, member 12
Protein class	FDA approved drug targets Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (PC-3, SCLC-21H, U-2197)
HPA (normal tissue):	Group enriched (parathyroid gland, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in Purkinje cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. External characterization data supports antibody staining but no internal RNA data available for correlation.
Reliability score	Approved based on 1 antibody. HPA027021
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027021

GENE INFORMATION
Gene name	KCNJ12 (HGNC Symbol)
Synonyms	hIRK1, IRK2, KCNJN1, Kir2.2, Kir2.2v
Description	Potassium channel, inwardly rectifying subfamily J, member 12 (HGNC Symbol)
Entrez gene summary	This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	21376197 - 21419872
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184185 (version 83.38)
Entrez gene	3768
UniProt	Q14500 (UniProt - Evidence at protein level)
neXtProt	NX_Q14500
Antibodypedia	KCNJ12 antibodies

PROTEIN BROWSER

KCNJ12-001	KCNJ12-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNJ12-001 ENSP00000463778 ENST00000583088	Q14500 [Direct mapping] ATP-sensitive inward rectifier potassium channel 12 Show all	Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0006936 [muscle contraction] GO:0007268 [synaptic transmission] GO:0008016 [regulation of heart contraction] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0031224 [intrinsic component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0051289 [protein homotetramerization] Show all	433 aa 49 kDa	No	3
KCNJ12-002 ENSP00000328150 ENST00000331718	Q14500 [Direct mapping] ATP-sensitive inward rectifier potassium channel 12 Show all	Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0006936 [muscle contraction] GO:0007268 [synaptic transmission] GO:0008016 [regulation of heart contraction] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0031224 [intrinsic component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0051289 [protein homotetramerization] Show all	433 aa 49 kDa	No	3

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.