Expression of TACSTD2 in cancer - Summary

GENERAL INFORMATION
Gene name	TACSTD2
Gene description	Tumor-associated calcium signal transducer 2
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A-431, CAPAN-2, HaCaT)
HPA (normal tissue):	Tissue enhanced (esophagus)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Abundant cytoplasmic and membrane expression in respiratory and squamous epithelial cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA043104 , HPA055067 , CAB072852
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA043104	HPA055067	CAB072852

GENE INFORMATION
Gene name	TACSTD2 (HGNC Symbol)
Synonyms	EGP-1, GA733-1, M1S1, TROP2
Description	Tumor-associated calcium signal transducer 2 (HGNC Symbol)
Entrez gene summary	This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]
Chromosome	1
Cytoband	p32.1
Chromosome location (bp)	58575423 - 58577773
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184292 (version 83.38)
Entrez gene	4070
UniProt	P09758 (UniProt - Evidence at protein level)
neXtProt	NX_P09758
Antibodypedia	TACSTD2 antibodies

PROTEIN BROWSER

TACSTD2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TACSTD2-001 ENSP00000360269 ENST00000371225	P09758 [Direct mapping] Tumor-associated calcium signal transducer 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007601 [visual perception] GO:0008283 [cell proliferation] GO:0009925 [basal plasma membrane] GO:0010633 [negative regulation of epithelial cell migration] GO:0016020 [membrane] GO:0016328 [lateral plasma membrane] GO:0050678 [regulation of epithelial cell proliferation] GO:0051497 [negative regulation of stress fiber assembly] GO:0060675 [ureteric bud morphogenesis] GO:0070062 [extracellular exosome] GO:0090191 [negative regulation of branching involved in ureteric bud morphogenesis] GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading] GO:1900028 [negative regulation of ruffle assembly] GO:2000146 [negative regulation of cell motility] GO:2000738 [positive regulation of stem cell differentiation] Show all	323 aa 35.7 kDa	Yes	1