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TACSTD2

GENERAL INFORMATION

Gene name

 TACSTD2

Gene description

 Tumor-associated calcium signal transducer 2

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (esophagus)
GTEx:Tissue enhanced (esophagus, salivary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Abundant cytoplasmic and membrane expression in respiratory and squamous epithelial cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA043104 , HPA055067 , CAB072852
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, salivary gland)

GENE INFORMATION

Gene name

 TACSTD2 (HGNC Symbol)

Synonyms

 EGP-1, GA733-1, M1S1, TROP2

Description

 Tumor-associated calcium signal transducer 2 (HGNC Symbol)

Entrez gene summary

 This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

Chromosome

 1

Cytoband

 p32.1

Chromosome location (bp)

 58575423 - 58577773

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184292 (version 83.38)

Entrez gene

 4070

UniProt

 P09758 (UniProt - Evidence at protein level)

neXtProt

 NX_P09758

Antibodypedia

 TACSTD2 antibodies

PROTEIN BROWSER
TACSTD2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TACSTD2-001
ENSP00000360269
ENST00000371225
P09758 [Direct mapping]
Tumor-associated calcium signal transducer 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007601 [visual perception]
GO:0008283 [cell proliferation]
GO:0009925 [basal plasma membrane]
GO:0010633 [negative regulation of epithelial cell migration]
GO:0016020 [membrane]
GO:0016328 [lateral plasma membrane]
GO:0050678 [regulation of epithelial cell proliferation]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0060675 [ureteric bud morphogenesis]
GO:0070062 [extracellular exosome]
GO:0090191 [negative regulation of branching involved in ureteric bud morphogenesis]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1900028 [negative regulation of ruffle assembly]
GO:2000146 [negative regulation of cell motility]
GO:2000738 [positive regulation of stem cell differentiation]
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 323 aa
35.7 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.