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Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Few cases of adenocarcinomas of lung, malignant carcinoids, stomach and urothelial cancers showed weak to moderate cytoplasmic and occasional membranous/nuclear immunoreactivity. Remaining malignant tissues were mostly negative.
GENE INFORMATION
Gene name
SLIT3 (HGNC Symbol)
Synonyms
MEGF5, SLIL2, Slit-3, SLIT1, slit2
Description
Slit guidance ligand 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]