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SLIT3

GENERAL INFORMATION

Gene name

 SLIT3

Gene description

 Slit guidance ligand 3

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 1 antibody.
HPA051630
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SLIT3 (HGNC Symbol)

Synonyms

 MEGF5, SLIL2, Slit-3, SLIT1, slit2

Description

 Slit guidance ligand 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

Chromosome

 5

Cytoband

Chromosome location (bp)

 168661733 - 169301129

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184347 (version 83.38)

Entrez gene

 6586

UniProt

 O75094 (UniProt - Evidence at transcript level)

neXtProt

 NX_O75094

Antibodypedia

 SLIT3 antibodies

PROTEIN BROWSER
SLIT3-001
SLIT3-002
SLIT3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLIT3-001
ENSP00000430333
ENST00000519560
O75094 [Direct mapping]
Slit homolog 3 protein
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005739 [mitochondrion]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0030308 [negative regulation of cell growth]
GO:0032870 [cellular response to hormone stimulus]
GO:0035385 [Roundabout signaling pathway]
GO:0048495 [Roundabout binding]
GO:0048846 [axon extension involved in axon guidance]
GO:0050770 [regulation of axonogenesis]
GO:0050919 [negative chemotaxis]
GO:0051414 [response to cortisol]
GO:0061364 [apoptotic process involved in luteolysis]
GO:0070100 [negative regulation of chemokine-mediated signaling pathway]
Show all
 1523 aa
167.7 kDa 		Yes 0
SLIT3-002
ENSP00000332164
ENST00000332966
O75094 [Direct mapping]
Slit homolog 3 protein
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005739 [mitochondrion]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0009887 [organ morphogenesis]
GO:0010629 [negative regulation of gene expression]
GO:0030308 [negative regulation of cell growth]
GO:0032870 [cellular response to hormone stimulus]
GO:0035385 [Roundabout signaling pathway]
GO:0048495 [Roundabout binding]
GO:0048846 [axon extension involved in axon guidance]
GO:0050770 [regulation of axonogenesis]
GO:0050919 [negative chemotaxis]
GO:0051414 [response to cortisol]
GO:0061364 [apoptotic process involved in luteolysis]
GO:0070100 [negative regulation of chemokine-mediated signaling pathway]
Show all
 1530 aa
168.6 kDa 		Yes 0
SLIT3-201
ENSP00000384890
ENST00000404867
A0A0A0MSC8 [Direct mapping]
Slit homolog 3 protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
Show all
 1393 aa
153.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.