Expression of KNTC1 in cancer - Summary - The Human Protein Atlas

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KNTC1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KNTC1
Gene description	Kinetochore associated 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA025241
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and head and neck cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA025241

GENE INFORMATION
Gene name	KNTC1 (HGNC Symbol)
Synonyms	KIAA0166, ROD
Description	Kinetochore associated 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	122527246 - 122626396
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184445 (version 83.38)
Entrez gene	9735
UniProt	P50748 (UniProt - Evidence at protein level)
neXtProt	NX_P50748
Antibodypedia	KNTC1 antibodies

PROTEIN BROWSER

KNTC1-001	KNTC1-002	KNTC1-003	KNTC1-005	KNTC1-009	KNTC1-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KNTC1-001 ENSP00000328236 ENST00000333479	P50748 [Direct mapping] Kinetochore-associated protein 1 Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000777 [condensed chromosome kinetochore] GO:0000922 [spindle pole] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005828 [kinetochore microtubule] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0007067 [mitotic nuclear division] GO:0007093 [mitotic cell cycle checkpoint] GO:0007096 [regulation of exit from mitosis] GO:0007264 [small GTPase mediated signal transduction] GO:0015629 [actin cytoskeleton] GO:0051301 [cell division] GO:1990423 [RZZ complex] Show all	2209 aa 250.7 kDa	No	0
KNTC1-002 ENSP00000397992 ENST00000450485	E7ES84 [Direct mapping] Kinetochore-associated protein 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0015629 [actin cytoskeleton] Show all	1134 aa 129.2 kDa	No	0
KNTC1-003 ENSP00000408760 ENST00000436959	F5H5V0 [Direct mapping] Kinetochore-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		130 aa 14.7 kDa	No	0
KNTC1-005 ENSP00000397140 ENST00000423927	J3KQF2 [Direct mapping] Kinetochore-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		104 aa 11.6 kDa	No	0
KNTC1-009 ENSP00000439119 ENST00000546125	H0YFL5 [Direct mapping] Kinetochore-associated protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		208 aa 24.1 kDa	No	0
KNTC1-016 ENSP00000437344 ENST00000534995	F5H5V0 [Direct mapping] Kinetochore-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		130 aa 14.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.