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KNTC1

GENERAL INFORMATION

Gene name

 KNTC1

Gene description

 Kinetochore associated 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Tissue enhanced (testis)
FANTOM5:Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA025241
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION

Gene name

 KNTC1 (HGNC Symbol)

Synonyms

 KIAA0166, ROD

Description

 Kinetochore associated 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.31

Chromosome location (bp)

 122527246 - 122626396

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184445 (version 83.38)

Entrez gene

 9735

UniProt

 P50748 (UniProt - Evidence at protein level)

neXtProt

 NX_P50748

Antibodypedia

 KNTC1 antibodies

PROTEIN BROWSER
KNTC1-001
KNTC1-002
KNTC1-003
KNTC1-005
KNTC1-009
KNTC1-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KNTC1-001
ENSP00000328236
ENST00000333479
P50748 [Direct mapping]
Kinetochore-associated protein 1
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   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000278 [mitotic cell cycle]
GO:0000777 [condensed chromosome kinetochore]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005828 [kinetochore microtubule]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007067 [mitotic nuclear division]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007096 [regulation of exit from mitosis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015629 [actin cytoskeleton]
GO:0051301 [cell division]
GO:1990423 [RZZ complex]
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 2209 aa
250.7 kDa 		No 0
KNTC1-002
ENSP00000397992
ENST00000450485
E7ES84 [Direct mapping]
Kinetochore-associated protein 1
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0015629 [actin cytoskeleton]
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 1134 aa
129.2 kDa 		No 0
KNTC1-003
ENSP00000408760
ENST00000436959
F5H5V0 [Direct mapping]
Kinetochore-associated protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 130 aa
14.7 kDa 		No 0
KNTC1-005
ENSP00000397140
ENST00000423927
J3KQF2 [Direct mapping]
Kinetochore-associated protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 104 aa
11.6 kDa 		No 0
KNTC1-009
ENSP00000439119
ENST00000546125
H0YFL5 [Direct mapping]
Kinetochore-associated protein 1
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 208 aa
24.1 kDa 		No 0
KNTC1-016
ENSP00000437344
ENST00000534995
F5H5V0 [Direct mapping]
Kinetochore-associated protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 130 aa
14.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.