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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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POU3F2
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS
MOUSE BRAIN

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

POU3F2

Gene description

POU class 3 homeobox 2

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus)

Protein evidence

Evidence at protein level

DATA RELIABILITY

Reliability score

Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
N/A
Cerebral cortex
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Thyroid gland
N/A
Parathyroid gland
N/A
Adrenal gland
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Bone marrow
N/A
Lymph node
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Heart muscle
N/A
Skeletal muscle
N/A
Smooth muscle
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Gallbladder
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Salivary gland
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Small intestine
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
Prostate
N/A
Seminal vesicle
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
Endometrium
N/A
Fallopian tube
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Adipose tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW

Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus)

GENE INFORMATION

Gene name

POU3F2 (HGNC Symbol)

Synonyms

BRN2, OCT7, OTF7, POUF3

Description

POU class 3 homeobox 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]

Chromosome

6

Cytoband

q16.1

Chromosome location (bp)

98834592 - 98839490

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000184486 (version 83.38)

Entrez gene

5454

UniProt

P20265 (UniProt - Evidence at protein level)

neXtProt

NX_P20265

Antibodypedia

POU3F2 antibodies

PROTEIN BROWSER

POU3F2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

POU3F2-001
ENSP00000329170
ENST00000328345
P20265 [Direct mapping]
POU domain, class 3, transcription factor 2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007420 [brain development]
GO:0008284 [positive regulation of cell proliferation]
GO:0008544 [epidermis development]
GO:0010629 [negative regulation of gene expression]
GO:0014002 [astrocyte development]
GO:0014044 [Schwann cell development]
GO:0021799 [cerebral cortex radially oriented cell migration]
GO:0021869 [forebrain ventricular zone progenitor cell division]
GO:0021979 [hypothalamus cell differentiation]
GO:0021985 [neurohypophysis development]
GO:0022011 [myelination in peripheral nervous system]
GO:0030182 [neuron differentiation]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042802 [identical protein binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045595 [regulation of cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050770 [regulation of axonogenesis]
GO:0071310 [cellular response to organic substance]
Show all
443 aa
46.9 kDa
No 0

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