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PTP4A3

GENERAL INFORMATION

Gene name

 PTP4A3

Gene description

 Protein tyrosine phosphatase type IVA, member 3

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HDLM-2, U-266/84)
HPA (normal tissue):Group enriched (heart muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Caution, targets protein from more than one gene. Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA003281
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003281

GENE INFORMATION

Gene name

 PTP4A3 (HGNC Symbol)

Synonyms

 PRL-3, PRL-R, PRL3

Description

 Protein tyrosine phosphatase type IVA, member 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 141391993 - 141432454

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184489 (version 83.38)

Entrez gene

 11156

UniProt

 O75365 (UniProt - Evidence at protein level)

neXtProt

 NX_O75365

Antibodypedia

 PTP4A3 antibodies

PROTEIN BROWSER
PTP4A3-001
PTP4A3-002
PTP4A3-003
PTP4A3-004
PTP4A3-201
PTP4A3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTP4A3-001
ENSP00000428976
ENST00000521578
O75365 [Direct mapping]
Protein tyrosine phosphatase type IVA 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0004727 [prenylated protein tyrosine phosphatase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0043542 [endothelial cell migration]
Show all
 173 aa
19.5 kDa 		No 0
PTP4A3-002
ENSP00000428758
ENST00000520105
O75365 [Direct mapping]
Protein tyrosine phosphatase type IVA 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004727 [prenylated protein tyrosine phosphatase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0043542 [endothelial cell migration]
Show all
 148 aa
16.8 kDa 		No 0
PTP4A3-003
ENSP00000430332
ENST00000524028
E5RFQ4 [Direct mapping]
Protein tyrosine phosphatase type IVA 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 87 aa
10.4 kDa 		No 0
PTP4A3-004
ENSP00000428725
ENST00000523147
E5RGR3 [Direct mapping]
Protein tyrosine phosphatase type IVA 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 70 aa
8 kDa 		No 0
PTP4A3-201
ENSP00000332274
ENST00000329397
O75365 [Direct mapping]
Protein tyrosine phosphatase type IVA 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0004727 [prenylated protein tyrosine phosphatase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0007219 [Notch signaling pathway]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0043117 [positive regulation of vascular permeability]
GO:0043542 [endothelial cell migration]
GO:1900746 [regulation of vascular endothelial growth factor signaling pathway]
Show all
 173 aa
19.5 kDa 		No 0
PTP4A3-202
ENSP00000331730
ENST00000349124
O75365 [Direct mapping]
Protein tyrosine phosphatase type IVA 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004727 [prenylated protein tyrosine phosphatase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0043542 [endothelial cell migration]
Show all
 148 aa
16.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.