Tissue expression of PTP4A3 - Summary - The Human Protein Atlas

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PTP4A3

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PTP4A3
Gene description	Protein tyrosine phosphatase type IVA, member 3
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (heart muscle, skeletal muscle)
GTEx:	Expressed in all
FANTOM5:	Tissue enhanced (skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Caution, targets protein from more than one gene. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA003281
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (heart muscle, skeletal muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skeletal muscle)

GENE INFORMATION
Gene name	PTP4A3 (HGNC Symbol)
Synonyms	PRL-3, PRL-R, PRL3
Description	Protein tyrosine phosphatase type IVA, member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	141391993 - 141432454
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184489 (version 83.38)
Entrez gene	11156
UniProt	O75365 (UniProt - Evidence at protein level)
neXtProt	NX_O75365
Antibodypedia	PTP4A3 antibodies

PROTEIN BROWSER

PTP4A3-001	PTP4A3-002	PTP4A3-003	PTP4A3-004	PTP4A3-201	PTP4A3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTP4A3-001 ENSP00000428976 ENST00000521578	O75365 [Direct mapping] Protein tyrosine phosphatase type IVA 3 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0004727 [prenylated protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0043542 [endothelial cell migration] Show all	173 aa 19.5 kDa	No	0
PTP4A3-002 ENSP00000428758 ENST00000520105	O75365 [Direct mapping] Protein tyrosine phosphatase type IVA 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004727 [prenylated protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0043542 [endothelial cell migration] Show all	148 aa 16.8 kDa	No	0
PTP4A3-003 ENSP00000430332 ENST00000524028	E5RFQ4 [Direct mapping] Protein tyrosine phosphatase type IVA 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		87 aa 10.4 kDa	No	0
PTP4A3-004 ENSP00000428725 ENST00000523147	E5RGR3 [Direct mapping] Protein tyrosine phosphatase type IVA 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		70 aa 8 kDa	No	0
PTP4A3-201 ENSP00000332274 ENST00000329397	O75365 [Direct mapping] Protein tyrosine phosphatase type IVA 3 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0004727 [prenylated protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0006470 [protein dephosphorylation] GO:0007219 [Notch signaling pathway] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0043117 [positive regulation of vascular permeability] GO:0043542 [endothelial cell migration] GO:1900746 [regulation of vascular endothelial growth factor signaling pathway] Show all	173 aa 19.5 kDa	No	0
PTP4A3-202 ENSP00000331730 ENST00000349124	O75365 [Direct mapping] Protein tyrosine phosphatase type IVA 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004727 [prenylated protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0043542 [endothelial cell migration] Show all	148 aa 16.8 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.