Expression of GAST in cancer - Summary - The Human Protein Atlas

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GAST

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GAST
Gene description	Gastrin
Protein class	Cancer-related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (pancreatic cancer, stomach cancer)
HPA (cell line):	Group enriched (BEWO, HaCaT, hTCEpi)
HPA (normal tissue):	Tissue enriched (stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in a subset of cells in stomach

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB000038
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (pancreatic cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB000038

GENE INFORMATION
Gene name	GAST (HGNC Symbol)
Synonyms	GAS
Description	Gastrin (HGNC Symbol)
Entrez gene summary	Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	41712326 - 41715969
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184502 (version 83.38)
Entrez gene	2520
UniProt	P01350 (UniProt - Evidence at protein level)
neXtProt	NX_P01350
Antibodypedia	GAST antibodies

PROTEIN BROWSER

GAST-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GAST-001 ENSP00000331358 ENST00000329402	P01350 [Direct mapping] Gastrin Gastrin-71 Gastrin-52 Big gastrin Gastrin Gastrin-14 Gastrin-6 A0A0E3VY36 [Target identity:100%; Query identity:100%] Gastrin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0032094 [response to food] Show all	101 aa 11.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.