Expression of CDCA2 in cancer - Summary - The Human Protein Atlas

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CDCA2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CDCA2
Gene description	Cell division cycle associated 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear membrane expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. External characterization data supports antibody staining.
Reliability score	Approved based on 2 antibodies. HPA026293 , HPA030049
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and colorectal cancer (favourable).
Renal cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA026293	HPA030049

GENE INFORMATION
Gene name	CDCA2 (HGNC Symbol)
Synonyms	PPP1R81, Repo-Man
Description	Cell division cycle associated 2 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	p21.2
Chromosome location (bp)	25458997 - 25507920
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184661 (version 83.38)
Entrez gene	157313
UniProt	Q69YH5 (UniProt - Evidence at protein level)
neXtProt	NX_Q69YH5
Antibodypedia	CDCA2 antibodies

PROTEIN BROWSER

CDCA2-001	CDCA2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDCA2-001 ENSP00000328228 ENST00000330560	Q69YH5 [Direct mapping] Cell division cycle-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0035307 [positive regulation of protein dephosphorylation] GO:0051301 [cell division] Show all	1023 aa 112.7 kDa	No	0
CDCA2-002 ENSP00000370040 ENST00000380665	E9PEI0 [Direct mapping] Cell division cycle-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	1008 aa 111 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.