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AMER1

GENERAL INFORMATION

Gene name

 AMER1

Gene description

 APC membrane recruitment protein 1

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA065214
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Ovarian cancer

STAINING SUMMARY
HPA065214

GENE INFORMATION

Gene name

 AMER1 (HGNC Symbol)

Synonyms

 FAM123B, FLJ39827, RP11-403E24.2, WTX

Description

 APC membrane recruitment protein 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010]

Chromosome

 X

Cytoband

 q11.2

Chromosome location (bp)

 64185117 - 64205744

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184675 (version 83.38)

Entrez gene

 139285

UniProt

 Q5JTC6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5JTC6

Antibodypedia

 AMER1 antibodies

PROTEIN BROWSER
AMER1-001
AMER1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AMER1-001
ENSP00000364003
ENST00000374869
Q5JTC6 [Direct mapping]
APC membrane recruitment protein 1
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Disease related genes
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GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008013 [beta-catenin binding]
GO:0016055 [Wnt signaling pathway]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
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 804 aa
87.8 kDa 		No 0
AMER1-002
ENSP00000329117
ENST00000330258
Q5JTC6 [Direct mapping]
APC membrane recruitment protein 1
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0001822 [kidney development]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008013 [beta-catenin binding]
GO:0016055 [Wnt signaling pathway]
GO:0060348 [bone development]
GO:0060612 [adipose tissue development]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0072161 [mesenchymal cell differentiation involved in kidney development]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
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 1135 aa
124 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.